U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rfx7 regulatory factor X, 7 [ Mus musculus (house mouse) ]

Gene ID: 319758, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rfx7provided by MGI
Official Full Name
regulatory factor X, 7provided by MGI
Primary source
MGI:MGI:2442675
See related
Ensembl:ENSMUSG00000037674 AllianceGenome:MGI:2442675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rfxdc2; 2510005N23Rik; 9930116O05Rik; D130086K05Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human RFX7 (regulatory factor X7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.8), CNS E14 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rfx7 in Genome Data Viewer
Location:
9 D; 9 40.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72439346..72530231)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72532169..72622949)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5084 Neighboring gene meiosis-specific nuclear structural protein 1 Neighboring gene testis expressed gene 9 Neighboring gene predicted gene, 33004 Neighboring gene RIKEN cDNA 4930509E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E8299 Neighboring gene STARR-positive B cell enhancer ABC_E5085 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24596 Neighboring gene VISTA enhancer mm1473 Neighboring gene predicted gene, 23057 Neighboring gene STARR-positive B cell enhancer ABC_E893 Neighboring gene neural precursor cell expressed, developmentally down-regulated 4 Neighboring gene STARR-seq mESC enhancer starr_24604 Neighboring gene STARR-positive B cell enhancer ABC_E6764

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Liang S, et al. Mol Vis, 2004 Oct 8. PMID 15496829
  2. The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Castro W, et al. Nat Immunol, 2018 Aug. PMID 29967452, Free PMC Article
  3. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that Rfx7 is a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence
    Title: The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA-binding protein RFX7
Names
regulatory factor X domain containing 2 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033536.1 → NP_001028708.1  DNA-binding protein RFX7

    See identical proteins and their annotated locations for NP_001028708.1

    Status: VALIDATED

    Source sequence(s)
    AC111135, AC123683, AK090370, CK638728, CN537334
    Consensus CDS
    CCDS40686.1
    UniProtKB/Swiss-Prot
    F8VPJ6
    Related
    ENSMUSP00000127192.2, ENSMUST00000163401.9
    Conserved Domains (3) summary
    pfam05109
    Location:330 → 668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02257
    Location:105 → 181
    RFX_DNA_binding; RFX DNA-binding domain
    pfam18326
    Location:43 → 100
    RFX5_N; RFX5 N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    72439346..72530231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242754.4 → XP_011241056.1  DNA-binding protein RFX7 isoform X1

    See identical proteins and their annotated locations for XP_011241056.1

    UniProtKB/Swiss-Prot
    F8VPJ6
    Conserved Domains (3) summary
    pfam05109
    Location:330 → 668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02257
    Location:105 → 181
    RFX_DNA_binding; RFX DNA-binding domain
    pfam18326
    Location:43 → 100
    RFX5_N; RFX5 N-terminal domain

  2. XM_006511223.5 → XP_006511286.1  DNA-binding protein RFX7 isoform X1

    See identical proteins and their annotated locations for XP_006511286.1

    UniProtKB/Swiss-Prot
    F8VPJ6
    Conserved Domains (3) summary
    pfam05109
    Location:330 → 668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02257
    Location:105 → 181
    RFX_DNA_binding; RFX DNA-binding domain
    pfam18326
    Location:43 → 100
    RFX5_N; RFX5 N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8VPJ6.1 GenPept UniProtKB/Swiss-Prot:F8VPJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous