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Frmd6 FERM domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 319710, updated on 5-Mar-2024

Summary

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Official Symbol
Frmd6provided by MGI
Official Full Name
FERM domain containing 6provided by MGI
Primary source
MGI:MGI:2442579
See related
Ensembl:ENSMUSG00000048285 AllianceGenome:MGI:2442579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Willin; 2610019M19Rik; 4930488L10Rik
Summary
Acts upstream of or within apical constriction; cellular protein localization; and regulation of actin filament-based process. Located in apical junction complex. Is expressed in several structures, including lung; medulla oblongata basal plate; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human FRMD6 (FERM domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 12.7), limb E14.5 (RPKM 11.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 29.37 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (70872235..70949009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70825456..70902234)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32322 Neighboring gene STARR-seq mESC enhancer starr_32397 Neighboring gene predicted gene, 40437 Neighboring gene STARR-seq mESC enhancer starr_32400 Neighboring gene predicted gene, 51973 Neighboring gene STARR-positive B cell enhancer ABC_E4027 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71954025-71954293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71974587-71974696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71981618-71981801 Neighboring gene STARR-seq mESC enhancer starr_32405 Neighboring gene STARR-seq mESC enhancer starr_32406 Neighboring gene predicted gene, 32664 Neighboring gene predicted gene, 46355 Neighboring gene STARR-positive B cell enhancer ABC_E8488 Neighboring gene ARP10 actin-related protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury. Lyu C, et al. Sci Rep, 2020 Feb 5. PMID 32024965, Free PMC Article
  2. The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin. Wang Z, et al. Aging Cell, 2019 Apr. PMID 30667167, Free PMC Article
  3. Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. Moleirinho S, et al. PLoS One, 2013. PMID 23593160, Free PMC Article
  4. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595
  5. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Ishiuchi T, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685893

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.
    Title: Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.
  2. The aged CMECs utilize BDNF-TrkB-T1 signalling to recruit Willin as a downstream effector to further activate the Hippo pathway, which then promotes migration.
    Title: The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin.
  3. results suggest that the nectin-afadin interaction plays a role in the correct localization of Willin
    Title: Nectins localize Willin to cell-cell junctions.
  4. Willin is predominantly expressed in fibroblasts and that Willin expression activates the Hippo signaling cascade
    Title: Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts.
  5. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
    Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apical constriction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FERM domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418229.1 → NP_001405158.1  FERM domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132325, AC140360

  2. NM_001418230.1 → NP_001405159.1  FERM domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132325, AC140360

  3. NM_028127.4 → NP_082403.2  FERM domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_082403.2

    Status: VALIDATED

    Source sequence(s)
    AC132325, AC140360
    Consensus CDS
    CCDS25959.1
    UniProtKB/Swiss-Prot
    Q8BW34, Q8C0V9
    Related
    ENSMUSP00000052202.8, ENSMUST00000057859.9
    Conserved Domains (3) summary
    cd13185
    Location:227 → 335
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    pfam00373
    Location:123 → 234
    FERM_M; FERM central domain
    cl28922
    Location:15 → 120
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    70872235..70949009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515977.5 → XP_006516040.1  FERM domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006516040.1

    UniProtKB/Swiss-Prot
    Q8BW34, Q8C0V9
    Conserved Domains (3) summary
    cd13185
    Location:227 → 335
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    pfam00373
    Location:123 → 234
    FERM_M; FERM central domain
    cl28922
    Location:15 → 120
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006515979.5 → XP_006516042.1  FERM domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006516042.1

    Conserved Domains (3) summary
    smart00295
    Location:20 → 226
    B41; Band 4.1 homologues
    cd13185
    Location:219 → 327
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    cl28922
    Location:15 → 112
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_036157494.1 → XP_036013387.1  FERM domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8BW34, Q8C0V9
    Conserved Domains (3) summary
    cd13185
    Location:227 → 335
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    pfam00373
    Location:123 → 234
    FERM_M; FERM central domain
    cl28922
    Location:15 → 120
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0V9.2 GenPept UniProtKB/Swiss-Prot:Q8C0V9

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