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Cep295 centrosomal protein 295 [ Mus musculus (house mouse) ]

Gene ID: 319675, updated on 5-Mar-2024

Summary

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Official Symbol
Cep295provided by MGI
Official Full Name
centrosomal protein 295provided by MGI
Primary source
MGI:MGI:2442521
See related
Ensembl:ENSMUSG00000046111 AllianceGenome:MGI:2442521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1131; Kiaa1731; 5830418K08Rik; 5832426L23Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Predicted to be located in cytoplasm; mitotic spindle microtubule; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human CEP295 (centrosomal protein 295). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.7), testis adult (RPKM 4.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 4.79 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15228210..15269145, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15316914..15357849, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene small nucleolar RNA SNORA32 Neighboring gene predicted gene, 22579 Neighboring gene small Cajal body-specific RNA 9 Neighboring gene predicted gene, 24339 Neighboring gene STARR-seq mESC enhancer starr_23377 Neighboring gene STARR-seq mESC enhancer starr_23378 Neighboring gene predicted gene, 34973 Neighboring gene STARR-seq mESC enhancer starr_23379 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 295 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176976.5 → NP_795950.3  centrosomal protein of 295 kDa

    Status: VALIDATED

    Source sequence(s)
    AC154296, AC155259
    Consensus CDS
    CCDS52727.1
    UniProtKB/TrEMBL
    E9QPW4
    Related
    ENSMUSP00000096578.5, ENSMUST00000098979.12
    Conserved Domains (1) summary
    PTZ00121
    Location:26 → 538
    PTZ00121; MAEBL; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15228210..15269145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155053.1 → XP_036010946.1  centrosomal protein of 295 kDa isoform X16

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  2. XM_017313423.3 → XP_017168912.1  centrosomal protein of 295 kDa isoform X15

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  3. XM_036155050.1 → XP_036010943.1  centrosomal protein of 295 kDa isoform X11

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  4. XM_006510411.3 → XP_006510474.1  centrosomal protein of 295 kDa isoform X6

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  5. XM_030244413.2 → XP_030100273.1  centrosomal protein of 295 kDa isoform X10

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  6. XM_006510409.3 → XP_006510472.1  centrosomal protein of 295 kDa isoform X3

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  7. XM_017313422.3 → XP_017168911.1  centrosomal protein of 295 kDa isoform X8

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  8. XM_017313419.3 → XP_017168908.1  centrosomal protein of 295 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  9. XM_011242548.4 → XP_011240850.1  centrosomal protein of 295 kDa isoform X5

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:47 → 391
    PTZ00121; MAEBL; Provisional

  10. XM_036155052.1 → XP_036010945.1  centrosomal protein of 295 kDa isoform X13

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

  11. XM_030244414.2 → XP_030100274.1  centrosomal protein of 295 kDa isoform X13

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

  12. XM_030244415.2 → XP_030100275.1  centrosomal protein of 295 kDa isoform X13

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

  13. XM_011242550.4 → XP_011240852.1  centrosomal protein of 295 kDa isoform X14

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9

  14. XM_006510414.2 → XP_006510477.1  centrosomal protein of 295 kDa isoform X17

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  15. XM_036155051.1 → XP_036010944.1  centrosomal protein of 295 kDa isoform X12

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  16. XM_017313421.2 → XP_017168910.1  centrosomal protein of 295 kDa isoform X7

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  17. XM_017313420.2 → XP_017168909.1  centrosomal protein of 295 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    UniProtKB/TrEMBL
    A0A1N9NPH8
    Related
    ENSMUSP00000123788.4, ENSMUST00000161132.10
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  18. XM_030244412.1 → XP_030100272.1  centrosomal protein of 295 kDa isoform X9

    UniProtKB/TrEMBL
    E9QPW4
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  19. XM_011242547.2 → XP_011240849.1  centrosomal protein of 295 kDa isoform X2

    UniProtKB/Swiss-Prot
    Q0VF60, Q3UYP6, Q571B9, Q8BQ48, Q8CCJ2, Q8CDA9
    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional

  20. XM_017313424.3 → XP_017168913.1  centrosomal protein of 295 kDa isoform X18

    Conserved Domains (1) summary
    PTZ00121
    Location:74 → 586
    PTZ00121; MAEBL; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQ48.3 GenPept UniProtKB/Swiss-Prot:Q8BQ48

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