Agmo alkylglycerol monooxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agmoprovided by MGI
Official Full Name: alkylglycerol monooxygenaseprovided by MGI
Primary source: MGI:MGI:2442495
See related: Ensembl:ENSMUSG00000050103 AllianceGenome:MGI:2442495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem195; A530016O06Rik
Summary: Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process and membrane lipid metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 14.5), large intestine adult (RPKM 8.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 16.84 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (37291638..37632201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (37241639..37581932)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate a central role of tetrahydrobiopterin and alkylglycerol monooxygenase in ether lipid metabolism of murine macrophages.
Title: Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Results suggest a possible mechanism for Alkylglycerol monooxygenase (AGMO) in modulating macrophage platelet-activating factor (PAF) production by regulating cellular lyso-PAF levels.
Title: Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

30.MMHAP9FRB12.seq (e-PCR)
- UniSTS:123927

D17867 (e-PCR)
- UniSTS:124734

AI790538 (e-PCR)
- UniSTS:180388

NoName (e-PCR)
- UniSTS:495309

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glyceryl-ether monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceryl-ether monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glyceryl-ether monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glyceryl-ether monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ether lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in membrane lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkylglycerol monooxygenase

Names: transmembrane protein 195

NP_848882.2

EC 1.14.16.5

XP_011242177.1

EC 1.14.16.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178767.5 → NP_848882.2 alkylglycerol monooxygenase

See identical proteins and their annotated locations for NP_848882.2

Status: PROVISIONAL

Source sequence(s)

AK040702

Consensus CDS

CCDS49052.1

UniProtKB/Swiss-Prot

Q3TR15, Q8BS35, Q8C7H5, Q8CAA6

Related

ENSMUSP00000051441.8, ENSMUST00000049874.14

Conserved Domains (2) summary

COG3000
Location:43 → 256

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

pfam04116
Location:121 → 249

FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

37291638..37632201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243875.3 → XP_011242177.1 alkylglycerol monooxygenase isoform X1

Related

ENSMUSP00000123801.2, ENSMUST00000159998.8

Conserved Domains (1) summary

COG3000
Location:43 → 256

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]