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Slc25a40 solute carrier family 25, member 40 [ Mus musculus (house mouse) ]

Gene ID: 319653, updated on 21-Apr-2024

Summary

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Official Symbol
Slc25a40provided by MGI
Official Full Name
solute carrier family 25, member 40provided by MGI
Primary source
MGI:MGI:2442486
See related
Ensembl:ENSMUSG00000054099 AllianceGenome:MGI:2442486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230315F11Rik
Summary
Predicted to be involved in transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.3), CNS E18 (RPKM 3.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8472730..8504840)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8422730..8454839)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene DBF4 zinc finger Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Wang Y, et al. Nature, 2021 Nov. PMID 34707288, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in erythrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable mitochondrial glutathione transporter SLC25A40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289595.1 → NP_001276524.1  probable mitochondrial glutathione transporter SLC25A40 isoform a

    See identical proteins and their annotated locations for NP_001276524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK044260, AK079538, AK084797, BY368313
    Consensus CDS
    CCDS39010.1
    UniProtKB/Swiss-Prot
    Q3UVZ5, Q8BGP6, Q8BXT8
    Related
    ENSMUSP00000130630.2, ENSMUST00000170496.6
    Conserved Domains (1) summary
    pfam00153
    Location:14 → 135
    Mito_carr; Mitochondrial carrier protein

  2. NM_001289596.1 → NP_001276525.1  probable mitochondrial glutathione transporter SLC25A40 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK044260, AK079538, BY368313
    UniProtKB/Swiss-Prot
    Q8BGP6
    Conserved Domains (1) summary
    pfam00153
    Location:171 → 268
    Mito_carr; Mitochondrial carrier protein

  3. NM_178766.5 → NP_848881.2  probable mitochondrial glutathione transporter SLC25A40 isoform a

    See identical proteins and their annotated locations for NP_848881.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK044260, AK045863, AK079538, BY368313
    Consensus CDS
    CCDS39010.1
    UniProtKB/Swiss-Prot
    Q3UVZ5, Q8BGP6, Q8BXT8
    Related
    ENSMUSP00000067611.4, ENSMUST00000066921.10
    Conserved Domains (1) summary
    pfam00153
    Location:14 → 135
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8472730..8504840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503592.5 → XP_006503655.3  probable mitochondrial glutathione transporter SLC25A40 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:86 → 207
    Mito_carr; Mitochondrial carrier protein

  2. XM_006503591.5 → XP_006503654.1  probable mitochondrial glutathione transporter SLC25A40 isoform X1

    See identical proteins and their annotated locations for XP_006503654.1

    UniProtKB/Swiss-Prot
    Q3UVZ5, Q8BGP6, Q8BXT8
    Conserved Domains (1) summary
    pfam00153
    Location:14 → 135
    Mito_carr; Mitochondrial carrier protein

  3. XM_030254570.2 → XP_030110430.1  probable mitochondrial glutathione transporter SLC25A40 isoform X5

    Conserved Domains (1) summary
    pfam00153
    Location:14 → 135
    Mito_carr; Mitochondrial carrier protein

  4. XM_030254569.2 → XP_030110429.1  probable mitochondrial glutathione transporter SLC25A40 isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:171 → 268
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGP6.1 GenPept UniProtKB/Swiss-Prot:Q8BGP6

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