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Galm galactose mutarotase [ Mus musculus (house mouse) ]

Gene ID: 319625, updated on 5-Mar-2024

Summary

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Official Symbol
Galmprovided by MGI
Official Full Name
galactose mutarotaseprovided by MGI
Primary source
MGI:MGI:2442420
See related
Ensembl:ENSMUSG00000035473 AllianceGenome:MGI:2442420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A530057M15Rik
Summary
Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 44.1), liver adult (RPKM 34.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E3; 17 50.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80434886..80492461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80127458..80185032)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41626 Neighboring gene STARR-seq mESC enhancer starr_43299 Neighboring gene predicted gene, 23125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:80530153-80530306 Neighboring gene STARR-seq mESC enhancer starr_43303 Neighboring gene STARR-positive B cell enhancer ABC_E5630 Neighboring gene microRNA 12189 Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene serine and arginine-rich splicing factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Wada Y, et al. Genet Med, 2019 Jun. PMID 30451973
  2. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
  3. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldose 1-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose 1-epimerase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactose mutarotase
Names
aldose 1-epimerase
NP_795937.1
XP_006524453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176963.4 → NP_795937.1  galactose mutarotase

    See identical proteins and their annotated locations for NP_795937.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140361
    Consensus CDS
    CCDS28987.1
    UniProtKB/Swiss-Prot
    Q8K157
    UniProtKB/TrEMBL
    Q3TSZ4
    Related
    ENSMUSP00000040580.5, ENSMUST00000039205.11
    Conserved Domains (1) summary
    cd09019
    Location:21 → 339
    galactose_mutarotase_like; galactose mutarotase_like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80434886..80492461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524390.5 → XP_006524453.1  galactose mutarotase isoform X1

    Conserved Domains (1) summary
    cd09019
    Location:21 → 211
    galactose_mutarotase_like; galactose mutarotase_like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K157.1 GenPept UniProtKB/Swiss-Prot:Q8K157

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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