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Celf5 CUGBP, Elav-like family member 5 [ Mus musculus (house mouse) ]

Gene ID: 319586, updated on 5-Mar-2024

Summary

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Official Symbol
Celf5provided by MGI
Official Full Name
CUGBP, Elav-like family member 5provided by MGI
Primary source
MGI:MGI:2442333
See related
Ensembl:ENSMUSG00000034818 AllianceGenome:MGI:2442333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brunol5; 4930565A21Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site selection and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; sensory organ; thymus; and tooth. Orthologous to human CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 40.2), whole brain E14.5 (RPKM 38.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81295061..81318564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81459227..81482730, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear factor I/C Neighboring gene predicted gene, 53593 Neighboring gene predicted gene, 51811 Neighboring gene STARR-positive B cell enhancer ABC_E577 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene nicalin Neighboring gene sphingosine-1-phosphate receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CUGBP Elav-like family member 5
Names
bruno-like 5, RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311124.2 → NP_001298053.1  CUGBP Elav-like family member 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) use an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS78869.1
    UniProtKB/TrEMBL
    D3Z580
    Related
    ENSMUSP00000113592.2, ENSMUST00000120508.8
    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 355
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94 → 174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  2. NM_001311126.2 → NP_001298055.1  CUGBP Elav-like family member 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5'UTR and lacks exons in the 5' coding region and uses an alternate splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS78868.1
    UniProtKB/TrEMBL
    D3Z4C5
    Related
    ENSMUSP00000113784.2, ENSMUST00000120856.8
    Conserved Domains (2) summary
    TIGR01628
    Location:21 → 279
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:18 → 98
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  3. NM_001311127.2 → NP_001298056.1  CUGBP Elav-like family member 5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks exon in the 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS78867.1
    UniProtKB/TrEMBL
    D3Z588
    Related
    ENSMUSP00000113546.2, ENSMUST00000119060.8
    Conserved Domains (2) summary
    TIGR01628
    Location:22 → 280
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:19 → 99
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  4. NM_001374703.1 → NP_001361632.1  CUGBP Elav-like family member 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS88058.1
    UniProtKB/TrEMBL
    A0A5F8MPH2
    Related
    ENSMUSP00000158971.2, ENSMUST00000238823.2
    Conserved Domains (4) summary
    TIGR01628
    Location:9 → 358
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:95 → 175
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:357 → 435
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  5. NM_001379187.1 → NP_001366116.1  CUGBP Elav-like family member 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 363
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:95 → 175
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  6. NM_001379188.1 → NP_001366117.1  CUGBP Elav-like family member 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 362
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94 → 174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  7. NM_001379189.1 → NP_001366118.1  CUGBP Elav-like family member 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (3) summary
    cd12639
    Location:287 → 365
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:11 → 367
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:25 → 105
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  8. NM_001379190.1 → NP_001366119.1  CUGBP Elav-like family member 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (3) summary
    cd12639
    Location:281 → 359
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:5 → 361
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:19 → 99
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  9. NM_001379191.1 → NP_001366120.1  CUGBP Elav-like family member 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:55 → 313
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:52 → 132
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  10. NM_001379192.1 → NP_001366121.1  CUGBP Elav-like family member 5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:56 → 321
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:53 → 133
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  11. NM_001379193.1 → NP_001366122.1  CUGBP Elav-like family member 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:55 → 320
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:52 → 132
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  12. NM_001379194.1 → NP_001366123.1  CUGBP Elav-like family member 5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:27 → 285
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:24 → 104
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  13. NM_001379195.1 → NP_001366124.1  CUGBP Elav-like family member 5 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:28 → 293
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:25 → 105
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  14. NM_001379196.1 → NP_001366125.1  CUGBP Elav-like family member 5 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC159474
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 255
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:1 → 74
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  15. NM_001379197.1 → NP_001366126.1  CUGBP Elav-like family member 5 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC159474
    UniProtKB/TrEMBL
    Q8BJL3
    Related
    ENSMUST00000141207.8
    Conserved Domains (1) summary
    cd12635
    Location:24 → 104
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  16. NM_176954.4 → NP_795928.2  CUGBP Elav-like family member 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS48644.1
    UniProtKB/TrEMBL
    D3Z4T1
    Related
    ENSMUSP00000113675.2, ENSMUST00000118763.8
    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 356
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:95 → 175
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81295061..81318564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513743.4 → XP_006513806.1  CUGBP Elav-like family member 5 isoform X1

    Conserved Domains (4) summary
    TIGR01628
    Location:9 → 357
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94 → 174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:356 → 434
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  2. XM_036155811.1 → XP_036011704.1  CUGBP Elav-like family member 5 isoform X6

    Conserved Domains (3) summary
    cd12639
    Location:256 → 334
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:2 → 336
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1 → 74
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  3. XM_036155813.1 → XP_036011706.1  CUGBP Elav-like family member 5 isoform X8

    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 255
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:1 → 74
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  4. XM_036155812.1 → XP_036011705.1  CUGBP Elav-like family member 5 isoform X7

    UniProtKB/TrEMBL
    D3Z588
    Conserved Domains (2) summary
    TIGR01628
    Location:22 → 280
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:19 → 99
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  5. XM_030245117.2 → XP_030100977.2  CUGBP Elav-like family member 5 isoform X3

    Conserved Domains (3) summary
    cd12639
    Location:314 → 392
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:42 → 394
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:52 → 132
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  6. XM_036155810.1 → XP_036011703.1  CUGBP Elav-like family member 5 isoform X5

    Conserved Domains (2) summary
    TIGR01628
    Location:56 → 314
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:53 → 133
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  7. XM_006513744.5 → XP_006513807.1  CUGBP Elav-like family member 5 isoform X2

    Conserved Domains (3) summary
    cd12635
    Location:53 → 133
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:315 → 393
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:39 → 395
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  8. XM_006513748.4 → XP_006513811.1  CUGBP Elav-like family member 5 isoform X4

    Conserved Domains (3) summary
    cd12635
    Location:24 → 104
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:286 → 364
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:14 → 366
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein Strain
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