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Pld5 phospholipase D family member 5 [ Mus musculus (house mouse) ]

Gene ID: 319455, updated on 5-Mar-2024

Summary

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Official Symbol
Pld5provided by MGI
Official Full Name
phospholipase D family member 5provided by MGI
Primary source
MGI:MGI:2442056
See related
Ensembl:ENSMUSG00000055214 AllianceGenome:MGI:2442056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230365F16Rik
Summary
Predicted to enable catalytic activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human PLD5 (phospholipase D family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.0), whole brain E14.5 (RPKM 0.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H4; 1 81.9 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (175789867..176109078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175962301..176281512, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23805 Neighboring gene exonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_03104 Neighboring gene beclin 2 Neighboring gene STARR-seq mESC enhancer starr_03106 Neighboring gene RNA binding motif protein 8A2 Neighboring gene STARR-seq mESC enhancer starr_03107 Neighboring gene STARR-seq mESC enhancer starr_03109 Neighboring gene STARR-seq mESC enhancer starr_03110 Neighboring gene predicted gene, 46173 Neighboring gene predicted gene, 17965 Neighboring gene predicted gene, 36536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
  2. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive phospholipase D5
Names
inactive PLD 5
inactive choline phosphatase 5
inactive phosphatidylcholine-hydrolyzing phospholipase D5
phospholipase D5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195816.1 → NP_001182745.1  inactive phospholipase D5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC124684, AC153644, AK136851, AK136888, BU609501, CK626039
    Consensus CDS
    CCDS56660.1
    UniProtKB/TrEMBL
    D3YYN6
    Related
    ENSMUSP00000106797.2, ENSMUST00000111167.2
    Conserved Domains (3) summary
    cd09146
    Location:49 → 211
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:247 → 440
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:42 → 445
    PHA02820; phospholipase-D-like protein; Provisional

  2. NM_001357844.1 → NP_001344773.1  inactive phospholipase D5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124463, AC124684, AC147236, AC153644
    Conserved Domains (2) summary
    cd09146
    Location:19 → 181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217 → 410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

  3. NM_001357845.1 → NP_001344774.1  inactive phospholipase D5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124463, AC124684, AC147236, AC153644
    Conserved Domains (2) summary
    cd09146
    Location:19 → 181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217 → 410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

  4. NM_001357846.1 → NP_001344775.1  inactive phospholipase D5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153644, AK136888
    Conserved Domains (2) summary
    cd09149
    Location:101 → 294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:1 → 65
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  5. NM_001357847.1 → NP_001344776.1  inactive phospholipase D5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124463, AC124684, AC147236, AC153644
    Conserved Domains (2) summary
    cd09149
    Location:101 → 294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:1 → 65
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  6. NM_176916.4 → NP_795890.2  inactive phospholipase D5 isoform 1

    See identical proteins and their annotated locations for NP_795890.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124684, AC153644, AK136888, BU609501
    Consensus CDS
    CCDS15552.1
    UniProtKB/Swiss-Prot
    Q3UNN8, Q3UVW3, Q497Q7
    Related
    ENSMUSP00000069326.8, ENSMUST00000065967.14
    Conserved Domains (3) summary
    cd09146
    Location:111 → 273
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:309 → 502
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:104 → 507
    PHA02820; phospholipase-D-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    175789867..176109078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496897.4 → XP_006496960.1  inactive phospholipase D5 isoform X1

    Conserved Domains (2) summary
    cd09149
    Location:258 → 451
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:111 → 222
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  2. XM_006496900.5 → XP_006496963.1  inactive phospholipase D5 isoform X7

    See identical proteins and their annotated locations for XP_006496963.1

    UniProtKB/Swiss-Prot
    Q3UNN8
    Conserved Domains (2) summary
    cd09149
    Location:101 → 294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:1 → 65
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  3. XM_030254909.1 → XP_030110769.1  inactive phospholipase D5 isoform X7

    Conserved Domains (2) summary
    cd09149
    Location:101 → 294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:1 → 65
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  4. XM_030254898.2 → XP_030110758.1  inactive phospholipase D5 isoform X3

    Conserved Domains (2) summary
    cd09146
    Location:19 → 181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217 → 410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

  5. XM_030254896.2 → XP_030110756.1  inactive phospholipase D5 isoform X2

    Conserved Domains (2) summary
    cd09146
    Location:20 → 182
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:218 → 411
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

  6. XM_036165683.1 → XP_036021576.1  inactive phospholipase D5 isoform X7

    Conserved Domains (2) summary
    cd09149
    Location:101 → 294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:1 → 65
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  7. XM_030254901.2 → XP_030110761.1  inactive phospholipase D5 isoform X4

    Conserved Domains (2) summary
    cd09149
    Location:166 → 359
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:19 → 130
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  8. XM_006496898.5 → XP_006496961.1  inactive phospholipase D5 isoform X5

    Conserved Domains (2) summary
    cd09149
    Location:146 → 339
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:3 → 110
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  9. XM_011238827.4 → XP_011237129.1  inactive phospholipase D5 isoform X6

    Conserved Domains (2) summary
    cd09149
    Location:111 → 304
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    cl15239
    Location:4 → 75
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UNN8.1 GenPept UniProtKB/Swiss-Prot:Q3UNN8

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