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Adgrl3 adhesion G protein-coupled receptor L3 [ Mus musculus (house mouse) ]

Gene ID: 319387, updated on 21-Apr-2024

Summary

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Official Symbol
Adgrl3provided by MGI
Official Full Name
adhesion G protein-coupled receptor L3provided by MGI
Primary source
MGI:MGI:2441950
See related
Ensembl:ENSMUSG00000037605 AllianceGenome:MGI:2441950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LEC3; Lphn3; CIRL-3; Gm1379; mKIAA0768; 5430402I23Rik; D130075K09Rik
Summary
Enables calcium ion binding activity. Involved in several processes, including locomotion involved in locomotory behavior; nervous system development; and response to cocaine. Acts upstream of or within positive regulation of synapse assembly. Located in axon and cell-cell junction. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in ductus deferens; epididymis; esophagus; and ileum. Used to study attention deficit hyperactivity disorder. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 5.1), whole brain E14.5 (RPKM 4.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 D- E1; 5 42.62 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (81167600..81980556)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (81019085..81827825)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene mitochondrial carrier homolog 2 pseudogene Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_13499 Neighboring gene STARR-positive B cell enhancer mm9_chr5:81649196-81649497 Neighboring gene STARR-seq mESC enhancer starr_13500 Neighboring gene STARR-seq mESC enhancer starr_13501 Neighboring gene STARR-seq mESC enhancer starr_13503 Neighboring gene STARR-seq mESC enhancer starr_13504 Neighboring gene predicted gene, 46946 Neighboring gene STARR-seq mESC enhancer starr_13508 Neighboring gene STARR-seq mESC enhancer starr_13509 Neighboring gene STARR-seq mESC enhancer starr_13510 Neighboring gene RIKEN cDNA 1700031L13 gene Neighboring gene STARR-seq mESC enhancer starr_13513 Neighboring gene STARR-seq mESC enhancer starr_13514 Neighboring gene STARR-seq mESC enhancer starr_13515 Neighboring gene ribosomal protein L7, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3. Perry-Hauser NA, et al. J Biol Chem, 2022 Dec. PMID 36244455, Free PMC Article
  2. Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. Wang Y, et al. Proc Natl Acad Sci U S A, 2021 Nov 9. PMID 34732574, Free PMC Article
  3. Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Mortimer N, et al. Neuropharmacology, 2019 Sep 15. PMID 30849401
  4. Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release. Röthe J, et al. Cell Rep, 2019 Feb 5. PMID 30726739
  5. Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction. Orsini CA, et al. Mol Genet Genomic Med, 2016 May. PMID 27247960, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alternative splicing of latrophilin-3 controls synapse formation.
    Title: Alternative splicing of latrophilin-3 controls synapse formation.
  2. Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.
    Title: Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.
  3. Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
    Title: Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
  4. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
    Title: Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
  5. Study further validates Adgrl3 constitutive knockout mice as an experimental model of attention deficit/hyperactivity disorder while providing neuroanatomical targets for future studies involving ADGRL3 modified models.
    Title: Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation.
  6. Latrophilin-3 pancreatic variants couple to Gi proteins reducing cAMP. Latrophilin-3 activation in pancreatic islets reduces insulin secretion.
    Title: Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release.
  7. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.
    Title: Super-complexes of adhesion GPCRs and neural guidance receptors.
  8. The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
    Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
  9. Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation.
    Title: Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99439

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of postsynaptic specialization structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of postsynaptic specialization structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to cocaine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor L3
Names
G protein coupled receptor Lec3
calcium-independent alpha-latrotoxin receptor homolog 3
latrophilin-3
lectomedin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347367.2 → NP_001334296.1  adhesion G protein-coupled receptor L3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
    Consensus CDS
    CCDS84891.1
    UniProtKB/TrEMBL
    D3Z3X6, D3Z4V0
    Related
    ENSMUSP00000113836.2, ENSMUST00000118442.8

  2. NM_001347368.2 → NP_001334297.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    Consensus CDS
    CCDS84893.1
    UniProtKB/TrEMBL
    D3Z4V0, D3Z6H9
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1262
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. NM_001347369.2 → NP_001334298.1  adhesion G protein-coupled receptor L3 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
    Consensus CDS
    CCDS84894.1
    UniProtKB/TrEMBL
    K3W4M8
    Related
    ENSMUSP00000113600.2, ENSMUST00000122356.8

  4. NM_001347371.2 → NP_001334300.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    Consensus CDS
    CCDS84895.1
    UniProtKB/TrEMBL
    D3Z593, D3Z634
    Related
    ENSMUSP00000113374.2, ENSMUST00000122037.8

  5. NM_001359826.1 → NP_001346755.1  adhesion G protein-coupled receptor L3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104196, AC121837, AC155075, AK147374
    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (6) summary
    smart00303
    Location:643 → 695
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:324 → 388
    HormR; Domain present in hormone receptors
    pfam02354
    Location:969 → 1298
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:397 → 617
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16005
    Location:703 → 969
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  6. NM_001359828.1 → NP_001346757.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
    UniProtKB/Swiss-Prot
    Q3UHI7, Q3UM79, Q504Z9, Q5HZJ6, Q80T56, Q80TS3
    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  7. NM_001359829.1 → NP_001346758.1  adhesion G protein-coupled receptor L3 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1189
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. NM_001359830.1 → NP_001346759.1  adhesion G protein-coupled receptor L3 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd14964
    Location:945 → 969
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1273
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:942 → 1208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  9. NM_001359831.1 → NP_001346760.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    UniProtKB/Swiss-Prot
    Q3UHI7, Q3UM79, Q504Z9, Q5HZJ6, Q80T56, Q80TS3
    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  10. NM_001359832.1 → NP_001346761.1  adhesion G protein-coupled receptor L3 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1194 → 1523
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:631 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16005
    Location:937 → 1194
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  11. NM_001359833.1 → NP_001346762.1  adhesion G protein-coupled receptor L3 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:813 → 865
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1139 → 1468
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:568 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16005
    Location:873 → 1139
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  12. NM_001359834.1 → NP_001346763.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1266
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:631 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:940 → 964
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:937 → 1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  13. NM_198702.3 → NP_941991.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_941991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC104196, AC114425, AC155075, BC088989
    Consensus CDS
    CCDS39122.1
    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    81167600..81980556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249474.4 → XP_011247776.1  adhesion G protein-coupled receptor L3 isoform X27

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd14964
    Location:945 → 969
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1273
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:942 → 1208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_017320921.3 → XP_017176410.1  adhesion G protein-coupled receptor L3 isoform X30

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1264
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. XM_036165192.1 → XP_036021085.1  adhesion G protein-coupled receptor L3 isoform X36

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1186
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1186 → 1251
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. XM_036165186.1 → XP_036021079.1  adhesion G protein-coupled receptor L3 isoform X29

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1268
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:939 → 964
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:937 → 1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_036165189.1 → XP_036021082.1  adhesion G protein-coupled receptor L3 isoform X33

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1194
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1194 → 1259
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  6. XM_036165194.1 → XP_036021087.1  adhesion G protein-coupled receptor L3 isoform X38

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1246
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  7. XM_030254567.2 → XP_030110427.1  adhesion G protein-coupled receptor L3 isoform X22

    UniProtKB/TrEMBL
    D3Z4V0, D3Z6H7
    Related
    ENSMUSP00000113249.2, ENSMUST00000120445.8
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd14964
    Location:944 → 969
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1315
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:942 → 1208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. XM_011249461.4 → XP_011247763.1  adhesion G protein-coupled receptor L3 isoform X1

    UniProtKB/TrEMBL
    D3Z5M6
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1586
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  9. XM_011249471.4 → XP_011247773.1  adhesion G protein-coupled receptor L3 isoform X24

    UniProtKB/TrEMBL
    D3Z4V0
    Related
    ENSMUSP00000112388.2, ENSMUST00000117407.8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1306
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  10. XM_036165183.1 → XP_036021076.1  adhesion G protein-coupled receptor L3 isoform X23

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1310
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:939 → 964
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:937 → 1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  11. XM_036165184.1 → XP_036021077.1  adhesion G protein-coupled receptor L3 isoform X25

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1194
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1194 → 1301
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  12. XM_011249465.4 → XP_011247767.1  adhesion G protein-coupled receptor L3 isoform X4

    See identical proteins and their annotated locations for XP_011247767.1

    UniProtKB/TrEMBL
    K3W4M8
    Related
    ENSMUSP00000072336.5, ENSMUST00000072521.11
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1208
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1208 → 1543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  13. XM_036165169.1 → XP_036021062.1  adhesion G protein-coupled receptor L3 isoform X3

    UniProtKB/TrEMBL
    D3Z4S7
    Related
    ENSMUSP00000113694.2, ENSMUST00000121641.8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1577
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  14. XM_017320919.3 → XP_017176408.1  adhesion G protein-coupled receptor L3 isoform X26

    UniProtKB/TrEMBL
    D3Z4V0, D3Z6H9
    Related
    ENSMUSP00000113243.2, ENSMUST00000119385.8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1262
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  15. XM_030254564.2 → XP_030110424.1  adhesion G protein-coupled receptor L3 isoform X6

    UniProtKB/TrEMBL
    D3YTW7, K3W4M8
    Related
    ENSMUSP00000112823.2, ENSMUST00000121707.8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882 → 934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:942 → 1199
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1199 → 1534
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  16. XM_036165173.1 → XP_036021066.1  adhesion G protein-coupled receptor L3 isoform X9

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1195
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1195 → 1524
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  17. XM_036165187.1 → XP_036021080.1  adhesion G protein-coupled receptor L3 isoform X31

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1186
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1186 → 1249
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  18. XM_011249469.4 → XP_011247771.1  adhesion G protein-coupled receptor L3 isoform X11

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563 → 627
    HormR; Domain present in hormone receptors
    cd16005
    Location:929 → 1186
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1186 → 1515
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636 → 843
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  19. XM_036165170.1 → XP_036021063.1  adhesion G protein-coupled receptor L3 isoform X5

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1203
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1538
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  20. XM_036165171.1 → XP_036021064.1  adhesion G protein-coupled receptor L3 isoform X7

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1203
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1532
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  21. XM_036165185.1 → XP_036021078.1  adhesion G protein-coupled receptor L3 isoform X28

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1194
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1194 → 1257
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  22. XM_036165172.1 → XP_036021065.1  adhesion G protein-coupled receptor L3 isoform X8

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1194
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1194 → 1529
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  23. XM_036165174.1 → XP_036021067.1  adhesion G protein-coupled receptor L3 isoform X10

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1190
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1190 → 1519
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  24. XM_036165190.1 → XP_036021083.1  adhesion G protein-coupled receptor L3 isoform X34

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1244
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  25. XM_030254566.2 → XP_030110426.1  adhesion G protein-coupled receptor L3 isoform X12

    UniProtKB/TrEMBL
    K3W4M8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:864 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:924 → 1181
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1181 → 1510
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:631 → 838
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  26. XM_036165168.1 → XP_036021061.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    D3Z5M6
    Related
    ENSMUSP00000113482.2, ENSMUST00000120673.8
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877 → 929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558 → 622
    HormR; Domain present in hormone receptors
    cd16005
    Location:937 → 1203
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1203 → 1581
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:630 → 851
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  27. XM_036165200.1 → XP_036021093.1  adhesion G protein-coupled receptor L3 isoform X44

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1118 → 1183
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:863 → 888
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:861 → 1118
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  28. XM_036165199.1 → XP_036021092.1  adhesion G protein-coupled receptor L3 isoform X43

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1191
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  29. XM_036165201.1 → XP_036021094.1  adhesion G protein-coupled receptor L3 isoform X45

    UniProtKB/TrEMBL
    D3YWR3
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1178
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 770
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:858 → 883
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:856 → 1113
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  30. XM_036165188.1 → XP_036021081.1  adhesion G protein-coupled receptor L3 isoform X32

    UniProtKB/TrEMBL
    D3YWB1, D3Z4V0
    Related
    ENSMUSP00000112548.2, ENSMUST00000120292.8
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1247
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:876 → 901
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:874 → 1140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  31. XM_036165191.1 → XP_036021084.1  adhesion G protein-coupled receptor L3 isoform X35

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1242
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1135
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  32. XM_036165193.1 → XP_036021086.1  adhesion G protein-coupled receptor L3 isoform X37

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1233
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  33. XM_036165195.1 → XP_036021088.1  adhesion G protein-coupled receptor L3 isoform X39

    UniProtKB/TrEMBL
    D3Z4V0, D3Z6J2
    Related
    ENSMUSP00000113208.2, ENSMUST00000120128.8
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1203
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:876 → 901
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:874 → 1140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  34. XM_036165175.1 → XP_036021068.1  adhesion G protein-coupled receptor L3 isoform X13

    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1140
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  35. XM_036165177.1 → XP_036021070.1  adhesion G protein-coupled receptor L3 isoform X15

    UniProtKB/TrEMBL
    D3Z3G4
    Related
    ENSMUSP00000113950.2, ENSMUST00000117985.8
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1140
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1140 → 1469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  36. XM_036165197.1 → XP_036021090.1  adhesion G protein-coupled receptor L3 isoform X41

    UniProtKB/TrEMBL
    D3YU23, D3Z4V0
    Related
    ENSMUSP00000112731.2, ENSMUST00000118078.8
    Conserved Domains (8) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1131 → 1194
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:876 → 901
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:874 → 1131
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  37. XM_036165178.1 → XP_036021071.1  adhesion G protein-coupled receptor L3 isoform X16

    UniProtKB/TrEMBL
    D3Z593
    Related
    ENSMUSP00000113534.2, ENSMUST00000118034.8
    Conserved Domains (7) summary
    smart00284
    Location:137 → 393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814 → 866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495 → 559
    HormR; Domain present in hormone receptors
    cd16005
    Location:874 → 1131
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1131 → 1466
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:567 → 788
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  38. XM_036165196.1 → XP_036021089.1  adhesion G protein-coupled receptor L3 isoform X40

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1198
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1135
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  39. XM_036165176.1 → XP_036021069.1  adhesion G protein-coupled receptor L3 isoform X14

    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1135
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1470
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  40. XM_017320915.3 → XP_017176404.1  adhesion G protein-coupled receptor L3 isoform X17

    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1135 → 1464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:563 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:869 → 1135
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  41. XM_036165198.1 → XP_036021091.1  adhesion G protein-coupled receptor L3 isoform X42

    UniProtKB/TrEMBL
    D3Z4V0
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1189
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:871 → 896
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:869 → 1126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  42. XM_036165179.1 → XP_036021072.1  adhesion G protein-coupled receptor L3 isoform X18

    UniProtKB/TrEMBL
    D3Z593
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1461
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  43. XM_036165180.1 → XP_036021073.1  adhesion G protein-coupled receptor L3 isoform X19

    UniProtKB/TrEMBL
    D3Z593
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:809 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:869 → 1126
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1126 → 1455
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 783
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  44. XM_036165181.1 → XP_036021074.1  adhesion G protein-coupled receptor L3 isoform X20

    UniProtKB/TrEMBL
    D3Z3G4
    Conserved Domains (8) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1122 → 1451
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 770
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:858 → 883
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:856 → 1122
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  45. XM_036165182.1 → XP_036021075.1  adhesion G protein-coupled receptor L3 isoform X21

    UniProtKB/TrEMBL
    D3Z593
    Conserved Domains (7) summary
    smart00284
    Location:132 → 388
    OLF; Olfactomedin-like domains
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:490 → 554
    HormR; Domain present in hormone receptors
    cd16005
    Location:856 → 1113
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:43 → 123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1442
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:562 → 770
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TS3.3 GenPept UniProtKB/Swiss-Prot:Q80TS3

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