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Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 319263, updated on 11-Apr-2024

Summary

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Official Symbol
Pcmtd1provided by MGI
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1provided by MGI
Primary source
MGI:MGI:2441773
See related
Ensembl:ENSMUSG00000051285 AllianceGenome:MGI:2441773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8430411F12Rik; A030012M09Rik
Summary
Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in cellular protein modification process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; neural retina; testis; and vibrissa. Orthologous to human PCMTD1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 14.1), frontal lobe adult (RPKM 11.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A1; 1 2.08 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (7157301..7243852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (7087077..7173628)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37108 Neighboring gene STARR-seq mESC enhancer starr_00091 Neighboring gene STARR-seq mESC enhancer starr_00093 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00099 Neighboring gene STARR-seq mESC enhancer starr_00100 Neighboring gene STARR-positive B cell enhancer ABC_E10003 Neighboring gene STARR-positive B cell enhancer ABC_E4302 Neighboring gene STARR-seq mESC enhancer starr_00104 Neighboring gene STARR-seq mESC enhancer starr_00105 Neighboring gene predicted gene, 26983 Neighboring gene STARR-positive B cell enhancer ABC_E7713 Neighboring gene neuroblastoma ras oncogene, pseudogene 2 Neighboring gene adenosylhomocysteinase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article
  2. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, et al. Genomics, 1993 Nov. PMID 8288233
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC117877

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-L-isoaspartate O-methyltransferase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183028.3 → NP_898849.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    See identical proteins and their annotated locations for NP_898849.1

    Status: VALIDATED

    Source sequence(s)
    AI462192, AK018402, AK168606, BY282003
    Consensus CDS
    CCDS35508.1
    UniProtKB/Swiss-Prot
    P59913
    UniProtKB/TrEMBL
    Q3TGS5, Q6P1Z6
    Related
    ENSMUSP00000059261.10, ENSMUST00000061280.17
    Conserved Domains (2) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    cl17173
    Location:14 → 221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    7157301..7243852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495535.3 → XP_006495598.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006495598.1

    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

  2. XM_006495536.4 → XP_006495599.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006495599.1

    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

  3. XM_036165672.1 → XP_036021565.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_373188.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59913.1 GenPept UniProtKB/Swiss-Prot:P59913

Gene LinkOut

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