Npsr1 neuropeptide S receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npsr1provided by MGI
Official Full Name: neuropeptide S receptor 1provided by MGI
Primary source: MGI:MGI:2441738
See related: Ensembl:ENSMUSG00000043659 AllianceGenome:MGI:2441738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPRA; MVTR; VRR1; PGR14; Gpr154; 9330128H10Rik
Summary: Predicted to enable neuropeptide receptor activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of release of sequestered calcium ion into cytosol; and righting reflex. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A3- A4; 9 9.99 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (24009212..24229151)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (24097912..24317590)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptide S and its receptor NPSR enhance the susceptibility of hosts to pseudorabies virus infection.
Title: Neuropeptide S and its receptor NPSR enhance the susceptibility of hosts to pseudorabies virus infection.
Sociability and extinction of conditioned social fear is affected in neuropeptide S receptor-deficient mice.
Title: Sociability and extinction of conditioned social fear is affected in neuropeptide S receptor-deficient mice.
Neuropeptide-S-receptor deficiency affects sex-specific modulation of safety learning by pre-exposure to electric stimuli.
Title: Neuropeptide-S-receptor deficiency affects sex-specific modulation of safety learning by pre-exposure to electric stimuli.
Findings demonstrate that neuropeptide S, via selective activation of the neurons bearing neuropeptide S receptor in the subiculum complex, ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 in mice.
Title: Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex.
Study demonstrated that NPS produces anti-aggressive effects in mice through the selective activation of NPSR and that the endogenous NPS/NPSR system can exert a role in the control of aggressiveness levels under the present experimental conditions
Title: Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.
the deletion of NPSR did not lead to compensatory changes in the vigilance-promoting effects of the CRF and Hcrt-1/Ox-A systems.
Title: Paradoxical response to the sedative effects of diazepam and alcohol in C57BL/6J mice lacking the neuropeptide S receptor.
A single nucleotide polymorphism in Npsr1 that increases its activity is linked to higher anxiety.
Title: Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.
In conclusion, the present study indicates that the NPS/NPSR system does not tonically control locomotion, sensitivity to diazepam, anxiety, depressive-like behaviours, memory and pain transmission in mice.
Title: Behavioural phenotypic characterization of CD-1 mice lacking the neuropeptide S receptor.
These results support an important role of neuropeptide S in regulating locomotor activity.
Title: Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response.
NPSR1 is essential in mediating NPS effects on behavior.
Title: Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defecation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in righting reflex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropeptide S receptor

Names: G protein-coupled receptor 154; G protein-coupled receptor PGR14; vasotocin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175678.3 → NP_783609.1 neuropeptide S receptor

See identical proteins and their annotated locations for NP_783609.1

Status: VALIDATED

Source sequence(s)

AK033957

Consensus CDS

CCDS22930.1

UniProtKB/Swiss-Prot

Q80T64, Q8BYA1, Q8BZP8

UniProtKB/TrEMBL

A1KXK3

Related

ENSMUSP00000056432.5, ENSMUST00000059650.11

Conserved Domains (1) summary

cd15197
Location:50 → 341

7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

24009212..24229151

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313417.3 → XP_017168906.1 neuropeptide S receptor isoform X1

UniProtKB/Swiss-Prot

Q80T64, Q8BYA1, Q8BZP8

UniProtKB/TrEMBL

A1KXK3

Conserved Domains (1) summary

cd15197
Location:50 → 341

7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036155047.1 → XP_036010940.1 neuropeptide S receptor isoform X1

UniProtKB/Swiss-Prot

Q80T64, Q8BYA1, Q8BZP8

UniProtKB/TrEMBL

A1KXK3

Conserved Domains (1) summary

cd15197
Location:50 → 341

7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017313418.2 → XP_017168907.1 neuropeptide S receptor isoform X2

UniProtKB/TrEMBL

A6X922

Related

ENSMUSP00000115126.2, ENSMUST00000154644.2

Conserved Domains (2) summary

cd14964
Location:9 → 30

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 188

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily