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Sctr secretin receptor [ Mus musculus (house mouse) ]

Gene ID: 319229, updated on 11-Apr-2024

Summary

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Official Symbol
Sctrprovided by MGI
Official Full Name
secretin receptorprovided by MGI
Primary source
MGI:MGI:2441720
See related
Ensembl:ENSMUSG00000026387 AllianceGenome:MGI:2441720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6530402O03Rik
Summary
Enables secretin receptor activity. Involved in several processes, including diet induced thermogenesis; positive regulation of cAMP-mediated signaling; and water homeostasis. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 11.4), adrenal adult (RPKM 3.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Sctr in Genome Data Viewer
Location:
1 E2.3; 1 52.57 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119934710..119991269)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120006879..120063539)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 221 Neighboring gene predicted gene, 17973 Neighboring gene predicted gene, 33817 Neighboring gene predicted gene, 33764 Neighboring gene STARR-seq mESC enhancer starr_02045 Neighboring gene predicted gene, 41936 Neighboring gene transmembrane protein 37 Neighboring gene predicted gene, 41937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Secretin receptor-deficient mice exhibit robust food anticipatory activity. Sugiyama M, et al. Neurosci Lett, 2022 Feb 16. PMID 35051436
  2. Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity. Sugiyama M, et al. Neurosci Lett, 2020 Mar 23. PMID 32027952
  3. Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system. Bai J, et al. FASEB J, 2017 Apr. PMID 28082350
  4. Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex. Lee LT, et al. FASEB J, 2014 Jun. PMID 24599969, Free PMC Article
  5. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Glaser S, et al. Hepatology, 2010 Jul. PMID 20578263, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
    Title: Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
  2. Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
    Title: Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
  3. Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
    Title: Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
  4. Secretin receptor-deficient mice exhibit robust food anticipatory activity.
    Title: Secretin receptor-deficient mice exhibit robust food anticipatory activity.
  5. Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
    Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
  6. Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
    Title: Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
  7. High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
    Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
  8. The involvement of secretin (SCT) and its receptor (SCTR) in angiotensin II (ANGII)-mediated osmoregulation by forming SCTR/ angiotensin II type 1 receptor (AT1R) heteromer is well established. In this study, we demonstrated that SCTR/AT1R complex can mediate ANGII-induced aldosterone secretion/release through potentiating calcium mobilization.
    Title: Role of SCTR/AT1aR heteromer in mediating ANGII-induced aldosterone secretion.
  9. Enhanced senescence levels in cholangiocytes from Mdr2(-/-) mice were reversed to normal in SR(-/-)/Mdr2(-/-) mice.
    Title: Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(-/-) mice by diminishing senescence of cholangiocytes.
  10. Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.
    Title: Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC102218

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables secretin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables secretin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secretin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in diet induced thermogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of appetite IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of appetite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal water absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nutrient levels IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
secretin receptor
Names
SCT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012322.2 → NP_001012322.2  secretin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001012322.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK032652, BC089355
    Consensus CDS
    CCDS48341.1
    UniProtKB/TrEMBL
    H7BX37
    Related
    ENSMUSP00000072660.5, ENSMUST00000072886.11
    Conserved Domains (2) summary
    cd15275
    Location:153 → 419
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:77 → 140
    HRM; Hormone receptor domain

  2. NM_001311077.1 → NP_001298006.1  secretin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001298006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK032652, BC089355
    Consensus CDS
    CCDS78668.1
    UniProtKB/Swiss-Prot
    Q5FWI2, Q80T66
    Related
    ENSMUSP00000139932.2, ENSMUST00000189037.2
    Conserved Domains (2) summary
    pfam00002
    Location:138 → 383
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:63 → 125
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    119934710..119991269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529684.5 → XP_006529747.1  secretin receptor isoform X1

    Conserved Domains (2) summary
    cd15275
    Location:153 → 417
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:77 → 140
    HRM; Hormone receptor domain

  2. XM_006529686.5 → XP_006529749.1  secretin receptor isoform X2

    Conserved Domains (2) summary
    cd15275
    Location:138 → 404
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:63 → 125
    HRM; Hormone receptor domain

  3. XM_036165671.1 → XP_036021564.1  secretin receptor isoform X6

    Conserved Domains (3) summary
    pfam02793
    Location:77 → 140
    HRM; Hormone receptor domain
    cd14964
    Location:155 → 180
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:153 → 352
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_036165670.1 → XP_036021563.1  secretin receptor isoform X6

    Conserved Domains (3) summary
    pfam02793
    Location:77 → 140
    HRM; Hormone receptor domain
    cd14964
    Location:155 → 180
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:153 → 352
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_036165668.1 → XP_036021561.1  secretin receptor isoform X3

    Conserved Domains (2) summary
    cd15275
    Location:153 → 408
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:77 → 140
    HRM; Hormone receptor domain

  6. XM_011248029.2 → XP_011246331.1  secretin receptor isoform X4

    See identical proteins and their annotated locations for XP_011246331.1

    Conserved Domains (2) summary
    cd15275
    Location:67 → 333
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:2 → 54
    HRM; Hormone receptor domain

  7. XM_036165669.1 → XP_036021562.1  secretin receptor isoform X4

    Conserved Domains (2) summary
    cd15275
    Location:67 → 333
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:2 → 54
    HRM; Hormone receptor domain

  8. XM_006529688.4 → XP_006529751.1  secretin receptor isoform X4

    See identical proteins and their annotated locations for XP_006529751.1

    Conserved Domains (2) summary
    cd15275
    Location:67 → 333
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:2 → 54
    HRM; Hormone receptor domain

  9. XM_011248031.4 → XP_011246333.1  secretin receptor isoform X5

    Conserved Domains (2) summary
    cd15275
    Location:62 → 328
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    cl02422
    Location:22 → 49
    HRM; Hormone receptor domain

  10. XM_030254873.2 → XP_030110733.1  secretin receptor isoform X8

    Conserved Domains (2) summary
    cd14964
    Location:53 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:46 → 281
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  11. XM_006529689.4 → XP_006529752.1  secretin receptor isoform X7

    Conserved Domains (2) summary
    cd14964
    Location:53 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:46 → 283
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  12. XM_006529690.3 → XP_006529753.1  secretin receptor isoform X9

    Conserved Domains (2) summary
    cd14964
    Location:1 → 25
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 187
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_004942727.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWI2.1 GenPept UniProtKB/Swiss-Prot:Q5FWI2

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