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Nol4 nucleolar protein 4 [ Mus musculus (house mouse) ]

Gene ID: 319211, updated on 5-Mar-2024

Summary

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Official Symbol
Nol4provided by MGI
Official Full Name
nucleolar protein 4provided by MGI
Primary source
MGI:MGI:2441684
See related
Ensembl:ENSMUSG00000041923 AllianceGenome:MGI:2441684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1262; 1700013J13Rik; 4930568N03Rik
Summary
Predicted to be located in nucleolus. Is expressed in brain; neural retina; olfactory epithelium; and spinal cord. Orthologous to human NOL4 (nucleolar protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.4), CNS E18 (RPKM 10.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A2; 18 11.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (22826209..23174926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (22693152..23042640, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41676 Neighboring gene STARR-seq mESC enhancer starr_44026 Neighboring gene STARR-seq mESC enhancer starr_44028 Neighboring gene ASXL transcriptional regulator 3 Neighboring gene STARR-seq mESC enhancer starr_44029 Neighboring gene STARR-seq mESC enhancer starr_44030 Neighboring gene STARR-seq mESC enhancer starr_44031 Neighboring gene STARR-seq mESC enhancer starr_44032 Neighboring gene STARR-seq mESC enhancer starr_44033 Neighboring gene STARR-seq mESC enhancer starr_44034 Neighboring gene STARR-seq mESC enhancer starr_44036 Neighboring gene predicted gene, 22495 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs. Toor SM, et al. Front Genet, 2021. PMID 34868271, Free PMC Article
  2. Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells. Takayanagi-Kiya S, et al. Zoolog Sci, 2014 Nov. PMID 25366156
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161483.1 → NP_001154955.1  nucleolar protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5' terminal exon, resulting in a different 5' UTR and the use of an alternate start codon, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
    Source sequence(s)
    AK029800, BB263751, BB578752, BC056377
    Consensus CDS
    CCDS50235.1
    UniProtKB/Swiss-Prot
    P60954
    UniProtKB/TrEMBL
    Q8C0U4
    Related
    ENSMUSP00000080150.7, ENSMUST00000081423.13

  2. NM_001347509.1 → NP_001334438.1  nucleolar protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC102361, AC103368, AC131338
    Consensus CDS
    CCDS84363.1
    UniProtKB/TrEMBL
    E9Q947
    Related
    ENSMUSP00000130950.2, ENSMUST00000164186.8

  3. NM_001347510.1 → NP_001334439.1  nucleolar protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
    Source sequence(s)
    AC102361, AC103368, AC131338
    Consensus CDS
    CCDS84362.1
    UniProtKB/TrEMBL
    G3UW35
    Related
    ENSMUSP00000127870.2, ENSMUST00000164893.8

  4. NM_001361223.1 → NP_001348152.1  nucleolar protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (5) has a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC102361, AC103368, AC131338

  5. NM_001361224.1 → NP_001348153.1  nucleolar protein 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (6) has a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC102361, AC103368, AC131338

  6. NM_001361225.1 → NP_001348154.1  nucleolar protein 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 3. The resulting isoform (6) has a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC102361, AC103368, AC131338

  7. NM_199024.3 → NP_950189.2  nucleolar protein 4 isoform 2

    See identical proteins and their annotated locations for NP_950189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 3.
    Source sequence(s)
    AC102361, AC103368, AC131338
    Consensus CDS
    CCDS29093.2
    UniProtKB/Swiss-Prot
    P60954
    Related
    ENSMUSP00000095256.4, ENSMUST00000097651.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    22826209..23174926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250501.2 → XP_030106361.1  nucleolar protein 4 isoform X3

  2. XM_036161167.1 → XP_036017060.1  nucleolar protein 4 isoform X6

    Conserved Domains (1) summary
    NF033845
    Location:229 → 398
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  3. XM_030250502.2 → XP_030106362.1  nucleolar protein 4 isoform X3

  4. XM_006525999.4 → XP_006526062.1  nucleolar protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006526062.1

    UniProtKB/Swiss-Prot
    P60954
    Conserved Domains (1) summary
    pfam17921
    Location:15 → 50
    Integrase_H2C2; Integrase zinc binding domain

  5. XM_030250504.2 → XP_030106364.1  nucleolar protein 4 isoform X5

  6. XM_030250503.2 → XP_030106363.1  nucleolar protein 4 isoform X4

    Conserved Domains (1) summary
    pfam17921
    Location:15 → 50
    Integrase_H2C2; Integrase zinc binding domain

  7. XM_030250499.2 → XP_030106359.1  nucleolar protein 4 isoform X2

    Conserved Domains (1) summary
    pfam17921
    Location:37 → 91
    Integrase_H2C2; Integrase zinc binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60954.2 GenPept UniProtKB/Swiss-Prot:P60954

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