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mthl15 methuselah-like 15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318914, updated on 10-May-2024

Summary

Official Symbol
mthl15provided by FlyBase
Official Full Name
methuselah-like 15provided by FlyBase
Primary source
FLYBASE:FBgn0051720
Locus tag
Dmel_CG31720
See related
AllianceGenome:FB:FBgn0051720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31720; Dmel\CG31720
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
31B1-31B1; 2-40 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10234585..10238317, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10234585..10238317, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ovaries absent Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene maternal expression at 31B Neighboring gene antisense RNA:CR44995 Neighboring gene chico

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
methuselah-like 15
Names
CG31720-PC
CG31720-PD
mthl15-PC
mthl15-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10234585..10238317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164897.3NP_723538.3  methuselah-like 15, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723538.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCS3
    Conserved Domains (2) summary
    cl11637
    Location:247355
    Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...
    cl21561
    Location:385646
    7tm_4; Olfactory receptor
  2. NM_164896.2NP_723537.2  methuselah-like 15, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723537.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPD1
    Conserved Domains (1) summary
    cl11637
    Location:247355
    Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...