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rdgA retinal degeneration A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31826, updated on 10-May-2024

Summary

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Official Symbol
rdgAprovided by FlyBase
Official Full Name
retinal degeneration Aprovided by FlyBase
Primary source
FLYBASE:FBgn0261549
Locus tag
Dmel_CG42667
See related
AllianceGenome:FB:FBgn0261549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10966; CG12660; CG15352; CG34344; CG42667; dDGK2; dgk; DGK; dgk-5; DGK2; Dmel\CG42667; RdgA; RDGA; x35
Old locus tag
CG10966; CG12660; Dmel_CG10966; Dmel_CG12660; Dmel_CG15352; Dmel_CG34344
Summary
Predicted to enable diacylglycerol kinase activity. Involved in several processes, including deactivation of rhodopsin mediated signaling; rhodopsin mediated signaling pathway; and thermotaxis. Is expressed in Bolwig organ; adult head; eye; and spermatozoon. Orthologous to several human genes including DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
8B7-8C3; 1-26 cM
Exon count:
23
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8907068..9029476)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8801101..8923509)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44111 Neighboring gene RNA-binding motif protein 13 Neighboring gene enhancer of rudimentary Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43836 Neighboring gene mir-4964 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-31b stem loop Neighboring gene Nostrin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible. McKerrow WH, et al. BMC Genomics, 2017 Jul 10. PMID 28693467, Free PMC Article
  2. Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats. Masai I, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248222, Free PMC Article
  3. Immunolocalization of a Drosophila phosphatidylinositol transfer protein (rdgB) in normal and rdgA mutant photoreceptor cells with special reference to the subrhabdomeric cisternae. Suzuki E, et al. J Electron Microsc (Tokyo), 1994 Aug. PMID 7996077
  4. Structure of retinular cells in a Drosophila melanogaster visual mutant, rdgA, at early stages of degeneration. Matsumoto E, et al. Cell Tissue Res, 1988 May. PMID 3133115
  5. Analysis of photoreceptor membrane turnover in a Drosophila visual mutant, rdgA, by electron microscope autoradiography. Suzuki E, et al. J Electron Microsc (Tokyo), 1990. PMID 2358773

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced odor responses from antennal neurons of rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
    Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: 8922385-8922744 mobile_element_type = transposon:jockey{}87
  • Loc: 8927642-8928286 mobile_element_type = transposon:FB{}rdgA[FB.1613]
  • Loc: 8948814-8956265 mobile_element_type = transposon:roo{}89

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in photoreceptor cell maintenance TAS
Traceable Author Statement
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in rhodopsin mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in thermotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinal degeneration A
Names
CG42667-PA
CG42667-PB
CG42667-PC
CG42667-PD
CG42667-PE
CG42667-PG
CG42667-PH
CG42667-PI
CG42667-PJ
CG42667-PK
CG42667-PL
DAG kinase
DAG-kinase
diacylglycerol kinase
rdgA-PA
rdgA-PB
rdgA-PC
rdgA-PD
rdgA-PE
rdgA-PG
rdgA-PH
rdgA-PI
rdgA-PJ
rdgA-PK
rdgA-PL
receptor degeneration A
receptor-degeneration-I
NP_001036264.2
NP_001096916.1
NP_001096917.1
NP_001188564.1
NP_001188565.1
NP_001259366.1
NP_001259367.1
NP_001285027.1
NP_001285028.1
NP_001368977.1
NP_511092.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8907068..9029476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201635.1 → NP_001188564.1  retinal degeneration A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188564.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSN3
    Conserved Domains (8) summary
    smart00045
    Location:498 → 652
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:348 → 471
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:347 → 669
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:876 → 994
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:125 → 174
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:877 → 972
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:876 → 903
    ANK; ANK repeat [structural motif]
    cl00040
    Location:195 → 259
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  2. NM_001042799.2 → NP_001036264.2  retinal degeneration A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036264.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GPM5
    Conserved Domains (7) summary
    smart00045
    Location:498 → 652
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:348 → 471
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:347 → 669
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:858 → 976
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:125 → 174
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:859 → 954
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:858 → 885
    ANK; ANK repeat [structural motif]

  3. NM_001103447.4 → NP_001096917.1  retinal degeneration A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096917.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09103
    Conserved Domains (7) summary
    smart00045
    Location:531 → 685
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:381 → 504
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:380 → 702
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:891 → 1009
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:158 → 207
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:892 → 987
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:891 → 918
    ANK; ANK repeat [structural motif]

  4. NM_001103446.2 → NP_001096916.1  retinal degeneration A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096916.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09103
    Conserved Domains (7) summary
    smart00045
    Location:516 → 670
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:366 → 489
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:365 → 687
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:894 → 1012
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:143 → 192
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:895 → 990
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:894 → 921
    ANK; ANK repeat [structural motif]

  5. NM_001272438.1 → NP_001259367.1  retinal degeneration A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH20
    Conserved Domains (7) summary
    smart00045
    Location:967 → 1121
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:817 → 940
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:816 → 1138
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:1327 → 1445
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:594 → 643
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:1328 → 1423
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1327 → 1354
    ANK; ANK repeat [structural motif]

  6. NM_001272437.1 → NP_001259366.1  retinal degeneration A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHG3
    Conserved Domains (7) summary
    smart00045
    Location:969 → 1123
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:814 → 942
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:813 → 1140
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:1329 → 1447
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:591 → 640
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:1330 → 1425
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1329 → 1356
    ANK; ANK repeat [structural motif]

  7. NM_001201636.1 → NP_001188565.1  retinal degeneration A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS31
    Conserved Domains (7) summary
    smart00045
    Location:959 → 1113
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:809 → 932
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:808 → 1130
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:1319 → 1437
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:592 → 641
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:1320 → 1415
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1319 → 1346
    ANK; ANK repeat [structural motif]

  8. NM_001298099.1 → NP_001285028.1  retinal degeneration A, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JEJ9
    Conserved Domains (4) summary
    smart00045
    Location:969 → 1123
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:814 → 942
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:813 → 1140
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00130
    Location:591 → 640
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  9. NM_001298098.1 → NP_001285027.1  retinal degeneration A, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285027.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JE67
    Conserved Domains (4) summary
    smart00045
    Location:969 → 1123
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:814 → 942
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:813 → 1140
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00130
    Location:591 → 640
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  10. NM_078537.3 → NP_511092.2  retinal degeneration A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511092.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JV38, A8JV40, Q09103, Q0KHU7, Q7YU71, Q8SY47, Q9W3A4
    Related
    FBpp0291800
    Conserved Domains (7) summary
    smart00045
    Location:964 → 1118
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:814 → 937
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:813 → 1135
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:1324 → 1442
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:591 → 640
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:1325 → 1420
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1324 → 1351
    ANK; ANK repeat [structural motif]

  11. NM_001382089.1 → NP_001368977.1  retinal degeneration A, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EFG8
    Conserved Domains (4) summary
    smart00045
    Location:969 → 1123
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:814 → 942
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20802
    Location:586 → 647
    C1_DGK_typeIV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type IV diacylglycerol kinases
    cd20855
    Location:661 → 727
    C1_DGK_typeIV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type IV diacylglycerol kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GPM5 A0A023GPM5
A0A6H2EFG8 A0A6H2EFG8
M9MS31 M9MS31
M9MSN3 M9MSN3
M9PH20 M9PH20
M9PHG3 M9PHG3
Q09103.2 Q09103
X2JE67 X2JE67
X2JEJ9 X2JEJ9

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