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DDX51 DEAD-box helicase 51 [ Homo sapiens (human) ]

Gene ID: 317781, updated on 5-Mar-2024

Summary

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Official Symbol
DDX51provided by HGNC
Official Full Name
DEAD-box helicase 51provided by HGNC
Primary source
HGNC:HGNC:20082
See related
Ensembl:ENSG00000185163 AllianceGenome:HGNC:20082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 5.1), ovary (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132136594..132144319, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132186137..132193862, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132621139..132628864, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene E1A binding protein p400 Neighboring gene small nucleolar RNA, H/ACA box 49 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132534021-132534992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132567429-132567930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132569347-132570207 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:132570983-132571159 Neighboring gene EP400 pseudogene 1 Neighboring gene uncharacterized LOC107987169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132611691-132612191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132626950-132627855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132638821-132639321 Neighboring gene nucleolar complex associated 4 homolog Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132662977-132663497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5114 Neighboring gene long intergenic non-protein coding RNA 2361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways. Wang X, et al. Sci Rep, 2016 May 20. PMID 27198888, Free PMC Article
  2. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. Wang W, et al. PLoS One, 2013. PMID 23741361, Free PMC Article
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug 22. PMID 21697133
  4. Directed proteomic analysis of the human nucleolus. Andersen JS, et al. Curr Biol, 2002 Jan 8. PMID 11790298
  5. GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. Watanabe S, et al. J Cell Sci, 2018 Aug 3. PMID 29991511

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggest that DDX51 aids cell cancer proliferation by regulating multiple signaling pathways
    Title: The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC42193, DKFZp686N2081

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX51
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEAD box protein 51
NP_778236.2
XP_011536558.1
XP_054188502.1
XP_054227887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175066.4 → NP_778236.2  ATP-dependent RNA helicase DDX51

    See identical proteins and their annotated locations for NP_778236.2

    Status: VALIDATED

    Source sequence(s)
    AC138466, AK097078, BC029279, BC040185, BC063603
    Consensus CDS
    CCDS41865.1
    UniProtKB/Swiss-Prot
    A8MPT9, Q5CZ71, Q8IXK5, Q8N8A6, Q96ED1
    UniProtKB/TrEMBL
    F1T0L5
    Related
    ENSP00000380495.3, ENST00000397333.4
    Conserved Domains (4) summary
    PRK01297
    Location:109 → 609
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    pfam00271
    Location:489 → 600
    Helicase_C; Helicase conserved C-terminal domain
    pfam15724
    Location:79 → 159
    TMEM119; TMEM119 family
    cl21455
    Location:205 → 449
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132136594..132144319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538256.2 → XP_011536558.1  ATP-dependent RNA helicase DDX51 isoform X1

    Conserved Domains (3) summary
    smart00487
    Location:213 → 455
    DEXDc; DEAD-like helicases superfamily
    pfam15724
    Location:79 → 159
    TMEM119; TMEM119 family
    cl21455
    Location:205 → 449
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160007.1 Reference GRCh38.p14 PATCHES

    Range
    43623..51348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332527.1 → XP_054188502.1  ATP-dependent RNA helicase DDX51 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132186137..132193862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371912.1 → XP_054227887.1  ATP-dependent RNA helicase DDX51 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8A6.3 GenPept UniProtKB/Swiss-Prot:Q8N8A6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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