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Sec22a SEC22 homolog A, vesicle trafficking protein [ Mus musculus (house mouse) ]

Gene ID: 317717, updated on 5-Mar-2024

Summary

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Official Symbol
Sec22aprovided by MGI
Official Full Name
SEC22 homolog A, vesicle trafficking proteinprovided by MGI
Primary source
MGI:MGI:2447876
See related
Ensembl:ENSMUSG00000034473 AllianceGenome:MGI:2447876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec22l2; 1810005C06Rik
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be integral component of membrane. Orthologous to human SEC22A (SEC22 homolog A, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.6), bladder adult (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 25.21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35131505..35184222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35311131..35363929, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53952 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene STARR-seq mESC enhancer starr_40734 Neighboring gene adenylate cyclase 5 Neighboring gene STARR-seq mESC enhancer starr_40735 Neighboring gene predicted gene, 46550 Neighboring gene predicted gene, 25179 Neighboring gene STARR-seq mESC enhancer starr_40736 Neighboring gene STARR-seq mESC enhancer starr_40737 Neighboring gene predicted gene, 25079 Neighboring gene predicted gene, 23518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle-trafficking protein SEC22a
Names
SEC22 vesicle trafficking protein homolog A
SEC22 vesicle trafficking protein homologe A
SEC22 vesicle trafficking protein-like 2
SEC22 vesicle trafficking protein-like A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418691.1 → NP_001405620.1  vesicle-trafficking protein SEC22a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154654

  2. NM_001418693.1 → NP_001405622.1  vesicle-trafficking protein SEC22a isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154654

  3. NM_001418695.1 → NP_001405624.1  vesicle-trafficking protein SEC22a isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154654
    UniProtKB/TrEMBL
    B7ZNW3
    Related
    ENSMUSP00000156164.2, ENSMUST00000232420.2

  4. NM_001418697.1 → NP_001405626.1  vesicle-trafficking protein SEC22a isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154654

  5. NM_001418700.1 → NP_001405629.1  vesicle-trafficking protein SEC22a isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154654

  6. NM_001418701.1 → NP_001405630.1  vesicle-trafficking protein SEC22a isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154654

  7. NM_001418702.1 → NP_001405631.1  vesicle-trafficking protein SEC22a isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154654

  8. NM_001418703.1 → NP_001405632.1  vesicle-trafficking protein SEC22a isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC154654

  9. NM_001418704.1 → NP_001405633.1  vesicle-trafficking protein SEC22a isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC154654

  10. NM_133704.5 → NP_598465.2  vesicle-trafficking protein SEC22a isoform 1

    See identical proteins and their annotated locations for NP_598465.2

    Status: VALIDATED

    Source sequence(s)
    AC154654
    Consensus CDS
    CCDS28138.1
    UniProtKB/Swiss-Prot
    Q8BH47, Q91Z54
    UniProtKB/TrEMBL
    B2RSR2
    Related
    ENSMUSP00000039568.5, ENSMUST00000043521.5
    Conserved Domains (2) summary
    COG5143
    Location:4 → 146
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    pfam13774
    Location:38 → 98
    Longin; Regulated-SNARE-like domain

RNA

  1. NR_184801.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154654

  2. NR_184802.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154654

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35131505..35184222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522235.4 → XP_006522298.1  vesicle-trafficking protein SEC22a isoform X2

    Conserved Domains (1) summary
    cd14824
    Location:21 → 142
    Longin; longin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH47.1 GenPept UniProtKB/Swiss-Prot:Q8BH47

Gene LinkOut

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