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VN1R3 vomeronasal 1 receptor 3 [ Homo sapiens (human) ]

Gene ID: 317702, updated on 5-Mar-2024

Summary

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Official Symbol
VN1R3provided by HGNC
Official Full Name
vomeronasal 1 receptor 3provided by HGNC
Primary source
HGNC:HGNC:19867
See related
AllianceGenome:HGNC:19867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V1RL3; FKSG46; V1RL3p
Summary
Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31807585..31808853, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (32194951..32196219, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31818906..31820174, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 67 pseudogene Neighboring gene protein phosphatase 2 catalytic subunit beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:31854092-31855001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7427 Neighboring gene RNA binding motif protein 22 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 3948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:31888713-31889912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31891365-31891865 Neighboring gene zinc finger protein 267 Neighboring gene PTPRF interacting protein alpha 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs. Young JM, et al. Genome Res, 2005 Feb. PMID 15653832, Free PMC Article
  2. Novel human vomeronasal receptor-like genes reveal species-specific families. Rodriguez I, et al. Curr Biol, 2002 Jun 25. PMID 12123587
  3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. Zhang J, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12826614, Free PMC Article
  4. Extreme variability among mammalian V1R gene families. Young JM, et al. Genome Res, 2010 Jan. PMID 19952141, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • MGC129709, MGC129710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pheromone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vomeronasal type-1 receptor 3
Names
V1R-like 3
V1RL3 pseudogene
V1r-like receptor 3
vomeronasal 1 receptor 3 pseudogene
vomeronasal 1 receptor 4 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174980.2 → NP_778145.2  vomeronasal type-1 receptor 3

    Status: VALIDATED

    Description
    Transcript Variant: This transcript represents the functional allele encoding the full-length protein.
    Source sequence(s)
    AF336873, BC107074
    UniProtKB/Swiss-Prot
    Q9BXE9
    Conserved Domains (1) summary
    cd13949
    Location:8 → 300
    7tm_V1R_pheromone; vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_171047.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) contains an indel in the CDS relative to the genome that creates a protein with shorter, unsupported N-terminus compared to variant 1.
    Source sequence(s)
    AC002519

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31807585..31808853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    32194951..32196219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_005664.3: Suppressed sequence

    Description
    NG_005664.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXE9.1 GenPept UniProtKB/Swiss-Prot:Q9BXE9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous