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ONECUT1 one cut homeobox 1 [ Homo sapiens (human) ]

Gene ID: 3175, updated on 10-Dec-2024

Summary

Official Symbol
ONECUT1provided by HGNC
Official Full Name
one cut homeobox 1provided by HGNC
Primary source
HGNC:HGNC:8138
See related
Ensembl:ENSG00000169856 MIM:604164; AllianceGenome:HGNC:8138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNF6; HNF-6; HNF6A
Summary
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Biased expression in liver (RPKM 2.0), gall bladder (RPKM 1.7) and 2 other tissues See more
Orthologs
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Genomic context

See ONECUT1 in Genome Data Viewer
Location:
15q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (52755053..52790336, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (50563333..50598640, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (53047250..53082533, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860078-52860826 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860827-52861573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9432 Neighboring gene cAMP regulated phosphoprotein 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52904295-52904794 Neighboring gene atos homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9434 Neighboring gene NANOG hESC enhancer GRCh37_chr15:52963789-52964290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6450 Neighboring gene uncharacterized LOC105370821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52979459-52979959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9437 Neighboring gene Sharpr-MPRA regulatory region 217 Neighboring gene uncharacterized LOC105370824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:53082820-53083588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:53083589-53084356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:53086613-53087310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:53087311-53088006 Neighboring gene uncharacterized LOC101928499 Neighboring gene uncharacterized LOC107983981

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of one cut homeobox 1 (ONECUT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell differentiation  
involved_in Notch signaling pathway  
involved_in anatomical structure morphogenesis  
involved_in cell fate commitment  
involved_in cell migration  
involved_in cilium assembly  
involved_in endoderm development  
involved_in epithelial cell development  
involved_in glucose metabolic process  
involved_in liver development  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in pancreatic A cell differentiation  
involved_in pancreatic D cell differentiation  
involved_in positive regulation of cell migration  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of DNA-templated transcription PubMed 
involved_in regulation of cell-matrix adhesion  
involved_in regulation of transcription by RNA polymerase II  
involved_in spleen development  
involved_in transforming growth factor beta receptor signaling pathway  
involved_in type B pancreatic cell differentiation  
Component Evidence Code Pubs
located_in chromatin  
is_active_in nucleus  

General protein information

Preferred Names
hepatocyte nuclear factor 6
Names
hepatocyte nuclear factor 6, alpha
one cut domain family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004498.4NP_004489.1  hepatocyte nuclear factor 6

    See identical proteins and their annotated locations for NP_004489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AA699732, AC016044, BM679470, U96173
    Consensus CDS
    CCDS10150.1
    UniProtKB/Swiss-Prot
    B2RTV4, Q99744, Q9UBC0, Q9UMR6
    UniProtKB/TrEMBL
    B2CNW3
    Related
    ENSP00000302630.4, ENST00000305901.7
    Conserved Domains (2) summary
    smart00389
    Location:385440
    HOX; Homeodomain
    pfam02376
    Location:290362
    CUT; CUT domain

RNA

  1. NR_073510.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA699732, AC016044, BM679470, BX118406, U96173

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    52755053..52790336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    50563333..50598640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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