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Luc7l2 LUC7-like 2 pre-mRNA splicing factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 312251, updated on 3-Apr-2024

Summary

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Official Symbol
Luc7l2provided by RGD
Official Full Name
LUC7-like 2 pre-mRNA splicing factorprovided by RGD
Primary source
RGD:1308651
See related
Ensembl:ENSRNOG00000006001 AllianceGenome:RGD:1308651
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity and mRNA binding activity. Predicted to be involved in mRNA splice site selection. Predicted to be located in nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human LUC7L2 (LUC7 like 2, pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 214.6), Adrenal (RPKM 188.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q23
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (68251435..68314861)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (67287593..67347986)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66290319..66357970)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCU) 2 Neighboring gene formation of mitochondrial complex V assembly factor 1 Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene insulin-induced gene 1 protein-like Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene killer cell lectin like receptor G2 Neighboring gene C-type lectin domain family 2, member L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Webby CJ, et al. Science, 2009 Jul 3. PMID 19574390
  2. Evidence for a direct role of the disease modifier SCNM1 in splicing. Howell VM, et al. Hum Mol Genet, 2007 Oct 15. PMID 17656373
  3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative RNA-binding protein Luc7-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107853.1 → NP_001101323.1  putative RNA-binding protein Luc7-like 2

    See identical proteins and their annotated locations for NP_001101323.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    B2RYP6, F1LP75
    Conserved Domains (1) summary
    pfam03194
    Location:5 → 241
    LUC7; LUC7 N_terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    68251435..68314861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286004.1 → XP_063142074.1  putative RNA-binding protein Luc7-like 2 isoform X6

  2. XM_006236316.5 → XP_006236378.1  putative RNA-binding protein Luc7-like 2 isoform X2

    See identical proteins and their annotated locations for XP_006236378.1

    UniProtKB/TrEMBL
    A0A8J8XLZ3
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  3. XM_063286003.1 → XP_063142073.1  putative RNA-binding protein Luc7-like 2 isoform X5

  4. XM_006236321.4 → XP_006236383.1  putative RNA-binding protein Luc7-like 2 isoform X4

    See identical proteins and their annotated locations for XP_006236383.1

    Related
    ENSRNOP00000086709.1
    Conserved Domains (1) summary
    pfam03194
    Location:5 → 241
    LUC7; LUC7 N_terminus

  5. XM_006236323.4 → XP_006236385.1  putative RNA-binding protein Luc7-like 2 isoform X7

    See identical proteins and their annotated locations for XP_006236385.1

    UniProtKB/TrEMBL
    A0A8I5Y5L3
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  6. XM_006236322.5 → XP_006236384.1  putative RNA-binding protein Luc7-like 2 isoform X7

    See identical proteins and their annotated locations for XP_006236384.1

    UniProtKB/TrEMBL
    A0A8I5Y5L3
    Related
    ENSRNOP00000077278.1
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  7. XM_063286000.1 → XP_063142070.1  putative RNA-binding protein Luc7-like 2 isoform X1

  8. XM_063286001.1 → XP_063142071.1  putative RNA-binding protein Luc7-like 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XLZ3

  9. XM_006236315.5 → XP_006236377.1  putative RNA-binding protein Luc7-like 2 isoform X2

    See identical proteins and their annotated locations for XP_006236377.1

    UniProtKB/TrEMBL
    A0A8J8XLZ3
    Related
    ENSRNOP00000008557.6
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  10. XM_063286002.1 → XP_063142072.1  putative RNA-binding protein Luc7-like 2 isoform X3

  11. XM_039107522.2 → XP_038963450.1  putative RNA-binding protein Luc7-like 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y5L3
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus
Nucleotide Protein Strain
Heading Accession and Version

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