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Pgd Phosphogluconate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31185, updated on 4-Apr-2024

Summary

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Official Symbol
Pgdprovided by FlyBase
Official Full Name
Phosphogluconate dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0004654
Locus tag
Dmel_CG3724
See related
AllianceGenome:FB:FBgn0004654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6-pgd; 6-Pgd; 6-PGD; 6Pgd; 6PGD; 6pgdh; 6Pgdh; 6PGDH; A7; CG3724; Dmel\CG3724; DmG6PDH; EG:87B1.4; l(1)2Dc; l(1)2De; l(1)A7; l(1)G0385; l(1)N1; l(1)N3[90]; l(1)Pgd; l(1)Pgd-A; l35; N1; Pdg; pgd; PGD
Summary
Predicted to enable NADP binding activity and phosphogluconate dehydrogenase (decarboxylating) activity. Involved in glucose homeostasis. Predicted to be active in cytosol. Is expressed in adult head; adult heart; embryonic/larval gut; gonad; and imaginal disc. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2D4-2D4; 1-0.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2145136..2148566)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2039169..2042599)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene polyhomeotic proximal Neighboring gene D-2-hydroxyglutaric acid dehydrogenase Neighboring gene bcn92 Neighboring gene wings apart-like Neighboring gene Cytochrome P450 4d1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of drosophila: selection and geographic differentiation. Begun DJ, et al. Genetics, 1994 Jan. PMID 8138153, Free PMC Article
  2. 6-Phosphogluconate dehydrogenase from Drosophila melanogaster. I. Purification and properties of the A isozyme. Williamson JH, et al. Biochem Genet, 1980 Feb. PMID 6770845
  3. Variations in the expression of the gene Pgd due to the effect of chromosomal rearrangements in Drosophila melanogaster. Slobodyanyuk SY, et al. Mol Gen Genet, 1983. PMID 6415362
  4. Molecular size studies on 6-phosphogluconate dehydrogenase. Kazazian HH Jr. Nature, 1966 Oct 8. PMID 5972220
  5. X-linked 6-phosphogluconate dehydrogenase in drosophila: subunit associations. Kazazian HH Jr, et al. Science, 1965 Dec 17. PMID 5866658

See all (187) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphogluconate dehydrogenase
Names
6-phosphogluconate
6-phosphogluconate dehydrogenase
CG3724-PA
CG3724-PB
NADP-6 phosphogluconate dehydrogenase
Pgd-PA
Pgd-PB
dehydrogenase
NP_001259175.1
NP_476860.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2145136..2148566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057512.3 → NP_476860.2  phosphogluconate dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476860.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41572, Q9W519
    UniProtKB/TrEMBL
    A0A0F6T1J9, M9PIS3
    Related
    FBpp0070368, FBtr0070384
    Conserved Domains (3) summary
    PRK09287
    Location:15 → 471
    PRK09287; 6-phosphogluconate dehydrogenase; Validated
    pfam00393
    Location:180 → 467
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    pfam03446
    Location:4 → 176
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase

  2. NM_001272246.1 → NP_001259175.1  phosphogluconate dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41572, Q9W519
    UniProtKB/TrEMBL
    A0A0F6T1J9, M9PIS3
    Conserved Domains (3) summary
    PRK09287
    Location:15 → 471
    PRK09287; 6-phosphogluconate dehydrogenase; Validated
    pfam00393
    Location:180 → 467
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    pfam03446
    Location:4 → 176
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PIS3 M9PIS3
P41572.1 P41572
Q95NF4 Q95NF4

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