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Schip1 schwannomin interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 30953, updated on 21-Apr-2024

Summary

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Official Symbol
Schip1provided by MGI
Official Full Name
schwannomin interacting protein 1provided by MGI
Primary source
MGI:MGI:1353557
See related
Ensembl:ENSMUSG00000027777 AllianceGenome:MGI:1353557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nf2ip; Schip-1
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including animal organ development; face morphogenesis; and fibroblast migration. Predicted to be located in cytoplasm. Predicted to be active in cell junction and plasma membrane. Is expressed in alimentary system; aorta; genitourinary system; nervous system; and sensory organ. Orthologous to human SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 31.5), cerebellum adult (RPKM 31.4) and 16 other tissues See more
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Genomic context

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Location:
3 E1; 3 31.44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67972135..68533815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (68064802..68626482)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07894 Neighboring gene predicted gene, 40068 Neighboring gene Iqcj and Schip1 fusion protein Neighboring gene STARR-seq mESC enhancer starr_07895 Neighboring gene IQ motif containing J Neighboring gene STARR-seq mESC enhancer starr_07896 Neighboring gene predicted pseudogene 5848 Neighboring gene predicted gene, 54202 Neighboring gene alkylglycerone phosphate synthase pseudogene Neighboring gene predicted gene 10723 Neighboring gene STARR-seq mESC enhancer starr_07901 Neighboring gene STARR-seq mESC enhancer starr_07902 Neighboring gene STARR-seq mESC enhancer starr_07905 Neighboring gene predicted gene, 22073 Neighboring gene predicted gene, 57836 Neighboring gene STARR-positive B cell enhancer ABC_E7916 Neighboring gene STARR-positive B cell enhancer ABC_E11191 Neighboring gene STARR-positive B cell enhancer mm9_chr3:68521546-68521847 Neighboring gene STARR-seq mESC enhancer starr_07911 Neighboring gene STARR-seq mESC enhancer starr_07912 Neighboring gene interleukin 12a Neighboring gene predicted gene, 35584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. Martin PM, et al. J Biol Chem, 2017 Feb 10. PMID 27979964, Free PMC Article
  2. Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Goutebroze L, et al. Mol Cell Biol, 2000 Mar. PMID 10669747, Free PMC Article
  3. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. Kwaśnicka-Crawford DA, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17045569
  4. The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Klingler E, et al. Development, 2015 Jun 1. PMID 25953347
  5. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. Martin PM, et al. J Neurosci, 2008 Jun 11. PMID 18550753, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/betaIV-spectrin network critical for node integrity
    Title: Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.
  2. CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
    Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.
  3. A new and early role for SCHIP1 during axon development and establishment of the anterior commissure, is identified.
    Title: The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Iqschfp

Readthrough gene: Iqschfp, Included gene: Iqcj

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within estrogen metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within luteinization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
schwannomin-interacting protein 1
Names
neurofibromatosis 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113420.1 → NP_001106891.1  schwannomin-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001106891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3, resulting in an isoform (b, also known as Schip-1b) that is shorter than isoform c.
    Source sequence(s)
    AC093360, BC060529, BY616163
    Consensus CDS
    CCDS50927.1
    UniProtKB/Swiss-Prot
    P0DPB4
    Related
    ENSMUSP00000129152.3, ENSMUST00000169909.10
    Conserved Domains (1) summary
    pfam10148
    Location:24 → 250
    SCHIP-1; Schwannomin-interacting protein 1

  2. NM_001113421.1 → NP_001106892.1  schwannomin-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001106892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c, also known as Schip-1a).
    Source sequence(s)
    AC093360, AK083464, BC060529, BY616163
    Consensus CDS
    CCDS50926.1
    UniProtKB/Swiss-Prot
    P0DPB4
    UniProtKB/TrEMBL
    A0A0A6YXQ5
    Related
    ENSMUSP00000029346.6, ENSMUST00000029346.13
    Conserved Domains (1) summary
    pfam10148
    Location:252 → 478
    SCHIP-1; Schwannomin-interacting protein 1

  3. NM_001282044.1 → NP_001268973.1  schwannomin-interacting protein 1 isoform e

    See identical proteins and their annotated locations for NP_001268973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus, compared to isoform c. Both variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AK146930, AW492234, BY281727, BY299001, BY623736
    Consensus CDS
    CCDS71249.1
    UniProtKB/TrEMBL
    A0A0A6YXQ5
    Related
    ENSMUSP00000138207.2, ENSMUST00000182719.8
    Conserved Domains (1) summary
    pfam10148
    Location:224 → 450
    SCHIP-1; Schwannomin-interacting protein 1

  4. NM_001282045.1 → NP_001268974.1  schwannomin-interacting protein 1 isoform e

    See identical proteins and their annotated locations for NP_001268974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus, compared to isoform c. Both variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AK083464, BB440451, BY616163, CA750719
    Consensus CDS
    CCDS71249.1
    UniProtKB/TrEMBL
    A0A0A6YXQ5
    Related
    ENSMUSP00000138245.2, ENSMUST00000182532.8
    Conserved Domains (1) summary
    pfam10148
    Location:224 → 450
    SCHIP-1; Schwannomin-interacting protein 1

  5. NM_013928.5 → NP_038956.2  schwannomin-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_038956.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 3. The encoded isoform (d) has a distinct and shorter N-terminus, compared to isoform c.
    Source sequence(s)
    BC060529, BY243167, BY616163
    Consensus CDS
    CCDS50929.1
    UniProtKB/TrEMBL
    A0A097PIJ2
    Related
    ENSMUSP00000126443.2, ENSMUST00000170788.9
    Conserved Domains (1) summary
    pfam10148
    Location:12 → 235
    SCHIP-1; Schwannomin-interacting protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67972135..68533815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DPB4.1 GenPept UniProtKB/Swiss-Prot:P0DPB4

Gene LinkOut

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