Usp21 ubiquitin specific peptidase 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp21provided by MGI
Official Full Name: ubiquitin specific peptidase 21provided by MGI
Primary source: MGI:MGI:1353665
See related: Ensembl:ENSMUSG00000053483 AllianceGenome:MGI:1353665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Usp16; Usp23; ESTM28
Summary: Enables thiol-dependent deubiquitinase and transcription coactivator activity. Involved in histone deubiquitination and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 28.1), CNS E14 (RPKM 27.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.3 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171109523..171115534, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171281949..171287961, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.
Title: USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.
Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.
Title: Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.
Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice.
Title: Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice.
USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse embryonic stem cells to maintain stemness.
Title: The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog.
USP21 recruits and stabilises Gli1 at the centrosome.
Title: The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Title: Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation.
Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination and RIG-I-mediated interferon signaling, while USP21 deletion resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN production, and antiviral responses.
Title: USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1.
Title: Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W53272 (e-PCR), detects polymorphism
- UniSTS:143014

STS-Z40895 (e-PCR)
- UniSTS:72126

G43283 (e-PCR)
- UniSTS:94919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables deNEDDylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 21

Names: deubiquitinating enzyme 21; ubiquitin specific protease 21; ubiquitin specific protease 23; ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific-processing protease 21

NP_038947.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013919.4 → NP_038947.2 ubiquitin carboxyl-terminal hydrolase 21

Status: VALIDATED

Source sequence(s)

AF177759, AK011148, BP770216, BY110597

Consensus CDS

CCDS35774.1

UniProtKB/Swiss-Prot

Q9D0R1, Q9QZL6

UniProtKB/TrEMBL

E9PUE2

Related

ENSMUSP00000064002.6, ENSMUST00000065941.12

Conserved Domains (1) summary

pfam00443
Location:212 → 556

UCH; Ubiquitin carboxyl-terminal hydrolase