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Fgd3 FYVE, RhoGEF and PH domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 30938, updated on 21-Apr-2024

Summary

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Official Symbol
Fgd3provided by MGI
Official Full Name
FYVE, RhoGEF and PH domain containing 3provided by MGI
Primary source
MGI:MGI:1353657
See related
Ensembl:ENSMUSG00000037946 AllianceGenome:MGI:1353657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE5; 5830461L01Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Involved in filopodium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including lung; musculature; nervous system; and spleen. Orthologous to human FGD3 (FYVE, RhoGEF and PH domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 7.4), thymus adult (RPKM 4.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 25.18 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49415030..49473783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49261554..49320313, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7237 Neighboring gene STARR-positive B cell enhancer ABC_E5396 Neighboring gene caspase recruitment domain family, member 19 Neighboring gene STARR-positive B cell enhancer ABC_E8525 Neighboring gene STARR-positive B cell enhancer ABC_E8526 Neighboring gene STARR-positive B cell enhancer mm9_chr13:49346365-49346665 Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene predicted gene, 52024 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene sushi domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene BICD cargo adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase Neighboring gene centromere protein P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Hayakawa M, et al. Genes Cells, 2008 Apr. PMID 18363964
  2. Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue. Pasteris NG, et al. Gene, 2000 Jan 25. PMID 10721717
  3. Multifactorial genetics of exencephaly in SELH/Bc mice. Juriloff DM, et al. Teratology, 2001 Oct. PMID 11598925
  4. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Sandberg M, et al. Neuron, 2016 Sep 21. PMID 27657450, Free PMC Article
  5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGD3, which was identified as a homologue of FGD1 but has been poorly characterized, has conserved the same motif and is down-regulated similarly by SCF(FWD1/beta-TrCP).
    Title: Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 3
Names
Fgd1 family, member 3
faciogenital dysplasia homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015759.2 → NP_056574.2  FYVE, RhoGEF and PH domain-containing protein 3

    See identical proteins and their annotated locations for NP_056574.2

    Status: VALIDATED

    Source sequence(s)
    AK157835
    Consensus CDS
    CCDS26499.1
    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    UniProtKB/TrEMBL
    Q3TNB8
    Related
    ENSMUSP00000105714.3, ENSMUST00000110087.9
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:606 → 710
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:527 → 580
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 474
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49415030..49473783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158066.1 → XP_036013959.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:570 → 674
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:491 → 544
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 460
    PH-like; Pleckstrin homology-like domain

  2. XM_006516929.5 → XP_006516992.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006516992.1

    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    UniProtKB/TrEMBL
    Q3TNB8
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:606 → 710
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:527 → 580
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 474
    PH-like; Pleckstrin homology-like domain

  3. XM_006516930.5 → XP_006516993.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006516993.1

    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    UniProtKB/TrEMBL
    Q3TNB8
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:606 → 710
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:527 → 580
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 474
    PH-like; Pleckstrin homology-like domain

  4. XM_036158065.1 → XP_036013958.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    UniProtKB/TrEMBL
    Q3TNB8
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:606 → 710
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:527 → 580
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 474
    PH-like; Pleckstrin homology-like domain

  5. XM_006516931.5 → XP_006516994.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006516994.1

    UniProtKB/Swiss-Prot
    A2RT26, O88842, Q8BQ72
    UniProtKB/TrEMBL
    Q3TNB8
    Related
    ENSMUSP00000048692.5, ENSMUST00000048716.11
    Conserved Domains (4) summary
    cd00160
    Location:156 → 335
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:606 → 710
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15740
    Location:527 → 580
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl17171
    Location:367 → 474
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88842.1 GenPept UniProtKB/Swiss-Prot:O88842

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