Lmcd1 LIM and cysteine-rich domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lmcd1provided by MGI
Official Full Name: LIM and cysteine-rich domains 1provided by MGI
Primary source: MGI:MGI:1353635
See related: Ensembl:ENSMUSG00000057604 AllianceGenome:MGI:1353635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: dyxin
Summary: Enables transcription corepressor activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and regulation of cardiac muscle hypertrophy. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and lung. Orthologous to human LMCD1 (LIM and cysteine rich domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 56.8), heart adult (RPKM 8.8) and 12 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 E3; 6 52.14 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (112250747..112307384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (112273758..112330423)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
Title: LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
Title: Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
Title: Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
LMCD1 acts as a repressor of NFATc1 in humans in mice in the induction of CDC6 and IL-33 expression during development of vascular lesions.
Title: Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions.
Gain- and loss-of-function studies show that LMCD1 controls protein synthesis, muscle fiber size, specific force, Ca(2+) handling, and fatigue resistance.
Title: LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
Study show that the novel LIM protein Lmcd1/Dyxin is both sufficient and necessary for cardiomyocyte hypertrophy.
Title: Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.
Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.
Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI071230 (e-PCR)
- UniSTS:244322

Lmcd1 (e-PCR), detects polymorphism
- UniSTS:531341

AW455500 (e-PCR)
- UniSTS:179431

NoName (e-PCR)
- UniSTS:235517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: LIM and cysteine-rich domains protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144799.3 → NP_659048.1 LIM and cysteine-rich domains protein 1

See identical proteins and their annotated locations for NP_659048.1

Status: VALIDATED

Source sequence(s)

AC153822

Consensus CDS

CCDS20403.1

UniProtKB/Swiss-Prot

Q8VEE1

UniProtKB/TrEMBL

Q3TVW6

Related

ENSMUSP00000032376.6, ENSMUST00000032376.6

Conserved Domains (3) summary

cd09340
Location:243 → 300

LIM1_Testin_like; The first LIM domain of Testin-like family

cd09829
Location:116 → 203

PET_testin; The PET domain of Testin

cl02475
Location:306 → 359

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers