U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zbtb18 zinc finger and BTB domain containing 18 [ Mus musculus (house mouse) ]

Gene ID: 30928, updated on 3-Apr-2024

Summary

Official Symbol
Zbtb18provided by MGI
Official Full Name
zinc finger and BTB domain containing 18provided by MGI
Primary source
MGI:MGI:1353609
See related
Ensembl:ENSMUSG00000063659 AllianceGenome:MGI:1353609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RP58; Zfp238; Znf238.; zfp-238
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and skeletal muscle tissue development. Acts upstream of or within several processes, including in utero embryonic development; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeleton. Used to study autosomal dominant non-syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 43.4), CNS E18 (RPKM 26.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zbtb18 in Genome Data Viewer
Location:
1 H4; 1 82.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177269892..177278330)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177442351..177450764)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178876211-178876412 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178880303-178880504 Neighboring gene predicted gene 15423 Neighboring gene thymoma viral proto-oncogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E7781 Neighboring gene STARR-seq mESC enhancer starr_03123 Neighboring gene predicted gene, 36904 Neighboring gene STARR-positive B cell enhancer ABC_E11110 Neighboring gene STARR-positive B cell enhancer mm9_chr1:179371945-179372246 Neighboring gene STARR-positive B cell enhancer ABC_E3338 Neighboring gene keratin 8 pseudogene Neighboring gene predicted gene, 30013 Neighboring gene microRNA 12179

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 18
Names
58 kDa repressor protein
transcriptional repressor RP58
zinc finger protein 238

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012330.2NP_001012330.1  zinc finger and BTB domain-containing protein 18 isoform 1

    See identical proteins and their annotated locations for NP_001012330.1

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS35800.1
    UniProtKB/TrEMBL
    H7BX69
    Related
    ENSMUSP00000091831.4, ENSMUST00000094276.5
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001355098.2NP_001342027.1  zinc finger and BTB domain-containing protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS35800.1
    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001355099.2NP_001342028.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS15553.1
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001355100.2NP_001342029.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS15553.1
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001355101.2NP_001342030.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS15553.1
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001355102.2NP_001342031.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS15553.1
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Related
    ENSMUSP00000141724.2, ENSMUST00000195612.2
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001355103.2NP_001342032.1  zinc finger and BTB domain-containing protein 18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS87929.1
    UniProtKB/TrEMBL
    A0A0A6YWR6, A0A0A6YY33
    Related
    ENSMUSP00000141663.2, ENSMUST00000193480.2
    Conserved Domains (1) summary
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
  8. NM_001421570.1NP_001408499.1  zinc finger and BTB domain-containing protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC120370
    UniProtKB/TrEMBL
    H7BX69
  9. NM_001421571.1NP_001408500.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
  10. NM_001421572.1NP_001408501.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
  11. NM_001421573.1NP_001408502.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120370
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
  12. NM_001421574.1NP_001408503.1  zinc finger and BTB domain-containing protein 18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120370
    UniProtKB/TrEMBL
    A0A0A6YWR6
  13. NM_013915.4NP_038943.3  zinc finger and BTB domain-containing protein 18 isoform 2

    See identical proteins and their annotated locations for NP_038943.3

    Status: VALIDATED

    Source sequence(s)
    AC120370
    Consensus CDS
    CCDS15553.1
    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Related
    ENSMUSP00000076463.7, ENSMUST00000077225.8
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    177269892..177278330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165663.1XP_036021556.1  zinc finger and BTB domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  2. XM_036165661.1XP_036021554.1  zinc finger and BTB domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  3. XM_036165664.1XP_036021557.1  zinc finger and BTB domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  4. XM_036165662.1XP_036021555.1  zinc finger and BTB domain-containing protein 18 isoform X1

    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006496889.5XP_006496952.1  zinc finger and BTB domain-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_006496952.1

    UniProtKB/TrEMBL
    H7BX69
    Conserved Domains (4) summary
    COG5048
    Location:303490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:421441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:10156
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:434456
    zf-H2C2_2; Zinc-finger double domain
  6. XM_030254847.2XP_030110707.1  zinc finger and BTB domain-containing protein 18 isoform X2

    UniProtKB/Swiss-Prot
    Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
    Conserved Domains (4) summary
    COG5048
    Location:294481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18324
    Location:1147
    BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
    pfam13465
    Location:425447
    zf-H2C2_2; Zinc-finger double domain