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Gnl3 guanine nucleotide binding protein nucleolar 3 [ Mus musculus (house mouse) ]

Gene ID: 30877, updated on 2-Apr-2024

Summary

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Official Symbol
Gnl3provided by MGI
Official Full Name
guanine nucleotide binding protein nucleolar 3provided by MGI
Primary source
MGI:MGI:1353651
See related
Ensembl:ENSMUSG00000042354 AllianceGenome:MGI:1353651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ns
Summary
Enables GTP binding activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; positive regulation of protein localization to chromosome, telomeric region; and stem cell division. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; liver lobe; lung; and metencephalon rest of alar plate marginal layer. Orthologous to human GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 33.9), liver E14.5 (RPKM 25.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30734390..30741088, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31012433..31019131, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene ES cell cis-regulatory motif 1d Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene predicted gene, 24916 Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleostemin in injury-induced liver regeneration. Shugo H, et al. Stem Cells Dev, 2012 Nov 1. PMID 22775537
  2. Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency. Qu J, et al. J Cell Biol, 2012 Jun 11. PMID 22689653, Free PMC Article
  3. Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability. Nomura J, et al. Stem Cells, 2009 May. PMID 19418458
  4. Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Ohmura M, et al. Stem Cells, 2008 Dec. PMID 18802033
  5. BAC transgenic expression efficiency: bicistronic versus ATG-fusion strategies. Lin T, et al. Genesis, 2007 Oct. PMID 17941047, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleostemin role in the mammary tumor progression.
    Title: Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.
  2. Nucleostemin expression participates in the preservation of the viability and integrity of embryonic stem cells.
    Title: Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
  3. nucleostemin protects hematopoietic stem cells (HSCs) from DNA damage accumulation and is required for the maintenance of HSCs.
    Title: Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.
  4. Mechanistic studies performed in mouse embryonic fibroblast cells showed that loss of nucleostemin triggers DNA damage and growth arrest independently of the p53 status or rRNA synthesis
    Title: Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells.
  5. NS plays a critical role in regeneration of both hepatic precursor cells and hepatocytes in response to liver injury.
    Title: Nucleostemin in injury-induced liver regeneration.
  6. Nucleostemin in the maintenance of ESC self-renewal, demonstrate the importance of rapid transit through G1 for this process, and expand the known classes of reprogramming factors.
    Title: Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.
  7. NS functions downstream of Myc as a rate-limiting regulator of cell proliferation and transformation.
    Title: Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.
  8. NS undergoes a ubiquitin- and MDM2-independent proteasomal degradation when intracellular GTP levels are markedly reduced
    Title: Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion.
  9. a complex composed of TERT, BRG1, and NS/GNL3L maintains the function of tumor initiating cells
    Title: Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.
  10. Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
    Title: Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46970

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein-like 3
Names
guanine nucleotide binding protein-like 3 (nucleolar)
nucleolar GTP-binding protein 3
nucleostemin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153547.6 → NP_705775.2  guanine nucleotide-binding protein-like 3

    See identical proteins and their annotated locations for NP_705775.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AA041888, AK077523, CJ071960, CJ089318
    Consensus CDS
    CCDS26905.1
    UniProtKB/Swiss-Prot
    Q811R9, Q811S8, Q8BK21, Q8CI11
    UniProtKB/TrEMBL
    Q3TK27
    Related
    ENSMUSP00000047119.7, ENSMUST00000037739.8
    Conserved Domains (3) summary
    cd04178
    Location:140 → 302
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    TIGR03596
    Location:130 → 395
    GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF
    pfam08701
    Location:16 → 93
    GN3L_Grn1; GNL3L/Grn1 putative GTPase

RNA

  1. NR_104298.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA041888, AK077523, AK167094, CJ071960, CJ089318
    Related
    ENSMUST00000226740.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30734390..30741088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178846.2: Suppressed sequence

    Description
    NM_178846.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI11.2 GenPept UniProtKB/Swiss-Prot:Q8CI11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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