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Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif 8 [ Mus musculus (house mouse) ]

Gene ID: 30806, updated on 11-Apr-2024

Summary

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Official Symbol
Adamts8provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 8provided by MGI
Primary source
MGI:MGI:1353468
See related
Ensembl:ENSMUSG00000031994 AllianceGenome:MGI:1353468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
METH2; METH-2
Summary
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016]
Expression
Broad expression in lung adult (RPKM 4.1), limb E14.5 (RPKM 1.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 16.49 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30853858..30875134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (30942562..30963838)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23671 Neighboring gene STARR-seq mESC enhancer starr_23672 Neighboring gene predicted gene, 31140 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 15 Neighboring gene predicted gene, 29724 Neighboring gene STARR-seq mESC enhancer starr_23676 Neighboring gene STARR-seq mESC enhancer starr_23679 Neighboring gene STARR-positive B cell enhancer ABC_E6719 Neighboring gene STARR-seq mESC enhancer starr_23682 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene STARR-seq mESC enhancer starr_23684 Neighboring gene predicted gene, 17508

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target. Omura J, et al. Circ Res, 2019 Oct 25. PMID 31556812
  2. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Rossier J, et al. Mol Psychiatry, 2015 Feb. PMID 25510509, Free PMC Article
  3. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. Georgiadis KE, et al. Genomics, 1999 Dec 1. PMID 10610729
  4. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Wågsäter D, et al. Atherosclerosis, 2008 Feb. PMID 17606262
  5. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. Vázquez F, et al. J Biol Chem, 1999 Aug 13. PMID 10438512

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAMTS8 deletion reduced pulmonary artery smooth muscle cell proliferation with AMPK up-regulation.
    Title: ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target.
  2. This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
    Title: Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
  3. ADAMTS-4 expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
    Title: ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 8
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326292.1 → NP_001313221.1  A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK043875, CT025653

  2. NM_013906.3 → NP_038934.2  A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_038934.2

    Status: REVIEWED

    Source sequence(s)
    AK043875, CT025653
    Consensus CDS
    CCDS22946.1
    UniProtKB/Swiss-Prot
    P57110
    UniProtKB/TrEMBL
    F8VQ15
    Related
    ENSMUSP00000069644.7, ENSMUST00000068135.13
    Conserved Domains (6) summary
    smart00209
    Location:545 → 597
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:234 → 441
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:234 → 444
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:52 → 152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706 → 825
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:463 → 529
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    30853858..30875134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57110.1 GenPept UniProtKB/Swiss-Prot:P57110

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