U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gcnt2 glucosaminyl (N-acetyl) transferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306860, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gcnt2provided by RGD
Official Full Name
glucosaminyl (N-acetyl) transferase 2provided by RGD
Primary source
RGD:1303198
See related
Ensembl:ENSRNOG00000023778 AllianceGenome:RGD:1303198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ignt; Gcnt6
Summary
Predicted to enable N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Predicted to be involved in several processes, including maintenance of lens transparency; positive regulation of heterotypic cell-cell adhesion; and positive regulation of intracellular signal transduction. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to human GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 53.1), Kidney (RPKM 49.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (24002592..24107339, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23796859..23901625, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21634546..21677477, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482840 Neighboring gene PAK1 interacting protein 1 Neighboring gene similar to human chromosome 6 open reading frame 52 Neighboring gene uncharacterized LOC103694058 Neighboring gene uncharacterized LOC120097872 Neighboring gene uncharacterized LOC120097871 Neighboring gene ribosomal protein L9-like Neighboring gene glucosaminyl (N-acetyl) transferase 2, pseudogene 1 Neighboring gene ribosomal protein L29, pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2 gene (GCNT2): association with autosomal recessive congenital cataracts. Pras E, et al. Invest Ophthalmol Vis Sci, 2004 Jun. PMID 15161861
  2. The molecular genetics of the mouse I beta-1,6-N-acetylglucosaminyltransferase locus. Twu YC, et al. Biochem Biophys Res Commun, 2003 Apr 11. PMID 12670491
  3. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Yu LC, et al. Blood, 2003 Mar 15. PMID 12424189
  4. Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling. Zhang H, et al. Cancer Res, 2011 Jul 15. PMID 21750175, Free PMC Article
  5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maintenance of lens transparency ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Names
I-branching beta-1,6-acetylglucosaminyltransferase
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like
glucosaminyl (N-acetyl) transferase 2 (I blood group)
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
glucosaminyl (N-acetyl) transferase 6
NP_001001511.1
NP_001387780.1
XP_038951614.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001511.4 → NP_001001511.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 2

    See identical proteins and their annotated locations for NP_001001511.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    Q6T5D9
    Related
    ENSRNOP00000029151.3, ENSRNOT00000035448.5
    Conserved Domains (1) summary
    pfam02485
    Location:95 → 356
    Branch; Core-2/I-Branching enzyme

  2. NM_001400851.1 → NP_001387780.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2KAF0, Q6T5E0
    Related
    ENSRNOP00000075374.1, ENSRNOT00000078010.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    24002592..24107339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095686.2 → XP_038951614.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1

    UniProtKB/TrEMBL
    F7FDB0, Q6T5E1
    Related
    ENSRNOP00000057083.3
    Conserved Domains (1) summary
    pfam02485
    Location:95 → 356
    Branch; Core-2/I-Branching enzyme

RNA

  1. XR_005495276.2 RNA Sequence

  2. XR_005495275.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous