Cxcl14 C-X-C motif chemokine ligand 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcl14provided by RGD
Official Full Name: C-X-C motif chemokine ligand 14provided by RGD
Primary source: RGD:1307406
See related: AllianceGenome:RGD:1307406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BRAK
Summary: Predicted to enable chemokine activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to act upstream of or within inner ear development; negative regulation of myoblast differentiation; and positive regulation of natural killer cell chemotaxis. Predicted to be located in Golgi apparatus. Orthologous to human CXCL14 (C-X-C motif chemokine ligand 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 102.7), Adrenal (RPKM 101.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (8323150..8331176)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (8317930..8325956)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9109731..9117754)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel.
Title: NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel.
IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression.
Title: IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression.
Differential expression of cxcl-14 during eruptive movement of rat molar germs
Title: Differential expression of cxcl-14 during eruptive movement of rat molar germs.
These results demonstrated for the first time that CXCL14 protein is present in a subset of hypothalamic neurons
Title: Immunohistochemical localization of chemokine CXCL14 in rat hypothalamic neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128165 (e-PCR)
- UniSTS:211473

CXCL14 (e-PCR)
- UniSTS:278259

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 14

Names: chemokine (C-X-C motif) ligand 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013137.3 → NP_001013155.1 C-X-C motif chemokine 14 precursor

See identical proteins and their annotated locations for NP_001013155.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

D4A5S7, Q8K453

Conserved Domains (1) summary

pfam00048
Location:33 → 86

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like