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Tcta T-cell leukemia translocation altered [ Rattus norvegicus (Norway rat) ]

Gene ID: 306587, updated on 13-Apr-2024

Summary

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Official Symbol
Tctaprovided by RGD
Official Full Name
T-cell leukemia translocation alteredprovided by RGD
Primary source
RGD:1359333
See related
AllianceGenome:RGD:1359333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be integral component of membrane. Orthologous to human TCTA (T cell leukemia translocation altered). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 333.3), Muscle (RPKM 196.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117867153..117871132, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108988588..108992324, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117079094..117082338, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene aminomethyltransferase Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene ras homolog family member A Neighboring gene ribosomal protein S15a, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Aplan PD, et al. Cancer Res, 1995 May 1. PMID 7728759
  2. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Kotake S, et al. Bone, 2009 Oct. PMID 19560569
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoclast fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell leukemia translocation-altered gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014005.2 → NP_001014027.1  T-cell leukemia translocation-altered gene protein homolog isoform 2

    See identical proteins and their annotated locations for NP_001014027.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5XIF1
    UniProtKB/TrEMBL
    A6I345
    Conserved Domains (1) summary
    pfam15128
    Location:15 → 106
    T_cell_tran_alt; T-cell leukemia translocation-altered

  2. NM_001401234.1 → NP_001388163.1  T-cell leukemia translocation-altered gene protein homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I346

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117867153..117871132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766514.4 → XP_008764736.3  T-cell leukemia translocation-altered gene protein homolog isoform X1

  2. XM_039081328.2 → XP_038937256.2  T-cell leukemia translocation-altered gene protein homolog isoform X4

  3. XM_039081327.2 → XP_038937255.2  T-cell leukemia translocation-altered gene protein homolog isoform X3

  4. XM_039081326.2 → XP_038937254.2  T-cell leukemia translocation-altered gene protein homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIF1.1 GenPept UniProtKB/Swiss-Prot:Q5XIF1

Gene LinkOut

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