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Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306243, updated on 11-Apr-2024

Summary

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Symbol
Cacna2d3provided by RGD
Full Name
calcium voltage-gated channel auxiliary subunit alpha2delta 3provided by RGD
Primary source
RGD:631361
See related
Ensembl:ENSRNOG00000031287 AllianceGenome:RGD:631361
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables voltage-gated calcium channel activity. Involved in calcium ion transport and cellular response to insulin-like growth factor stimulus. Predicted to be integral component of membrane. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 175.5), Testes (RPKM 28.5) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (4105048..4919037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (4098439..4912498, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (4871348..5795825, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 5A Neighboring gene ribosomal protein L5, pseudogene 1 Neighboring gene uncharacterized LOC103693891 Neighboring gene leucine-rich repeats and transmembrane domains 1 Neighboring gene ribosomal protein L7, pseudogene 11 Neighboring gene uncharacterized LOC134482443 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and cellular localization of the voltage-gated calcium channel α2δ3 in the rodent retina. Pérez de Sevilla Müller L, et al. J Comp Neurol, 2015 Jul 1. PMID 25631988, Free PMC Article
  2. Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3. Meyer JO, et al. Sci Rep, 2021 May 13. PMID 33986433, Free PMC Article
  3. Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1. Chu PJ, et al. J Mol Cell Cardiol, 2003 Feb. PMID 12606261
  4. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Davies A, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080692, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit alpha2delta-1 but not alpha2delta-3.
    Title: Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3.
  2. The expression of the alpha(2)delta(3) calcium channel subunit to multiple cell types suggests that this subunit participates widely in Ca-channel-mediated signaling in the retina.
    Title: Expression and cellular localization of the voltage-gated calcium channel α2δ3 in the rodent retina.
  3. all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.[Cacna2d3
    Title: The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-3
Names
calcium channel, voltage-dependent, alpha 2/delta 3 subunit
calcium channel, voltage-dependent, alpha2/delta subunit 3
voltage-gated calcium channel subunit alpha-2/delta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175595.2 → NP_783185.1  voltage-dependent calcium channel subunit alpha-2/delta-3 precursor

    See identical proteins and their annotated locations for NP_783185.1

    Status: PROVISIONAL

    Source sequence(s)
    AF486278
    UniProtKB/Swiss-Prot
    Q8CFG5
    UniProtKB/TrEMBL
    F1LSR8
    Related
    ENSRNOP00000042602.4, ENSRNOT00000048043.4
    Conserved Domains (3) summary
    cd01463
    Location:242 → 425
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:452 → 542
    Cache_1; Cache domain
    pfam08399
    Location:113 → 229
    VWA_N; VWA N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    4105048..4919037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275287.1 → XP_063131357.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2

    UniProtKB/Swiss-Prot
    Q8CFG5

  2. XM_063275286.1 → XP_063131356.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G6W1

  3. XM_063275289.1 → XP_063131359.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3

RNA

  1. XR_005494606.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFG5.1 GenPept UniProtKB/Swiss-Prot:Q8CFG5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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