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HCRTR1 hypocretin receptor 1 [ Homo sapiens (human) ]

Gene ID: 3061, updated on 11-Apr-2024

Summary

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Official Symbol
HCRTR1provided by HGNC
Official Full Name
hypocretin receptor 1provided by HGNC
Primary source
HGNC:HGNC:4848
See related
Ensembl:ENSG00000121764 MIM:602392; AllianceGenome:HGNC:4848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX1R; OXR1; ORXR1
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
1p35.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31617689..31634492)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31475343..31490165)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32083290..32093214)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903917 Neighboring gene Sharpr-MPRA regulatory region 14090 Neighboring gene uncharacterized LOC105378626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32034359-32034860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32041927-32042647 Neighboring gene tubulointerstitial nephritis antigen like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 571 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:32070860-32072059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32080194-32080980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32083206-32083895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090464-32090964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090965-32091465 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32110207-32110977 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32123622-32123860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32124291-32124792 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131402-32131941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131942-32132480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32133021-32133558 Neighboring gene uncharacterized LOC101929444

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation. Vitale RM, et al. Biomolecules, 2021 Aug 1. PMID 34439801, Free PMC Article
  2. Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender. Pulver A, et al. Brain Res, 2020 Nov 1. PMID 32652147
  3. Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour. Harro J, et al. Neuropharmacology, 2019 Sep 15. PMID 30742846
  4. Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes. Gottschalk MG, et al. Transl Psychiatry, 2019 Feb 4. PMID 30718541, Free PMC Article
  5. Orexin/hypocretin receptor, Orx(1), gene variants are associated with major depressive disorder. Cengiz M, et al. Int J Psychiatry Clin Pract, 2019 Jun. PMID 30596528

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
    Title: Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
  2. Internal and external modulation factors of the orexin system (REVIEW).
    Title: Internal and external modulation factors of the orexin system (REVIEW).
  3. Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
    Title: Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
  4. Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
    Title: Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
  5. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
    Title: Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
  6. Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.
    Title: Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.
  7. Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
    Title: Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
  8. TM4 and 5 of APJ act as the interaction interface of the APJ-OX1R heterodimer, and co-internalization could be disrupted by these peptides as well.
    Title: Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R.
  9. Study shows that homozygocity for the minor variant of the HCRTR1 gene (rs2271933, G1222A) that causes amino acid substitution (Ile408Val) was associated with aggressiveness measured with either self-reports or clinical interviews.
    Title: Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.
  10. A significant interaction effect between GHRL rs696217 and HCRTR1 rs2271933 was found to predict the Post-traumatic stress disorder symptoms Checklist (PCL-5) total score (P = 0.007).
    Title: The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables orexin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
orexin/Hypocretin receptor type 1
Names
hypocretin (orexin) receptor 1
hypocretin receptor type 1
orexin receptor 1
orexin receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001525.3 → NP_001516.2  orexin/Hypocretin receptor type 1

    See identical proteins and their annotated locations for NP_001516.2

    Status: REVIEWED

    Source sequence(s)
    AC114488
    Consensus CDS
    CCDS344.1
    UniProtKB/Swiss-Prot
    A8K3A6, O43613, Q9HBV6
    Related
    ENSP00000384387.2, ENST00000403528.7
    Conserved Domains (1) summary
    cd15208
    Location:47 → 369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31617689..31634492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446605.2 → XP_024302373.1  orexin/Hypocretin receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K3A6, O43613, Q9HBV6
    Conserved Domains (1) summary
    cd15208
    Location:47 → 369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017001107.2 → XP_016856596.1  orexin/Hypocretin receptor type 1 isoform X2

    UniProtKB/TrEMBL
    A6NMV7
    Related
    ENSP00000362809.1, ENST00000373705.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31475343..31490165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336200.1 → XP_054192175.1  orexin/Hypocretin receptor type 1 isoform X1

  2. XM_054336201.1 → XP_054192176.1  orexin/Hypocretin receptor type 1 isoform X1

  3. XM_054336202.1 → XP_054192177.1  orexin/Hypocretin receptor type 1 isoform X2

    UniProtKB/TrEMBL
    A6NMV7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43613.2 GenPept UniProtKB/Swiss-Prot:O43613

Gene LinkOut

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