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Bfar bifunctional apoptosis regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 304709, updated on 13-Apr-2024

Summary

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Symbol
Bfarprovided by RGD
Full Name
bifunctional apoptosis regulatorprovided by RGD
Primary source
RGD:1304791
See related
Ensembl:ENSRNOG00000003151 AllianceGenome:RGD:1304791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305537
Summary
Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 297.1), Muscle (RPKM 158.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bfar in Genome Data Viewer
Location:
10q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2059189..2092207)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (1552019..1585040)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (1464783..1497653)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547286 Neighboring gene uncharacterized LOC120095007 Neighboring gene poly(A)-specific ribonuclease Neighboring gene dynein light chain LC8-type 1 like Neighboring gene phospholipase A2, group X Neighboring gene large ribosomal subunit protein uL10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Zhang H, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10716992, Free PMC Article
  2. Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress. Rong J, et al. J Biol Chem, 2011 Jan 14. PMID 21068390, Free PMC Article
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables caspase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional apoptosis regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013125.2 → NP_001013143.1  bifunctional apoptosis regulator

    See identical proteins and their annotated locations for NP_001013143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    BC087103, FM033098, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5PQN2
    Related
    ENSRNOP00000004217.6, ENSRNOT00000004217.9
    Conserved Domains (2) summary
    cd09513
    Location:179 → 249
    SAM_BAR; SAM domain of BAR subfamily
    cd16497
    Location:32 → 77
    RING-HC_BAR; RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)

RNA

  1. NR_138253.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    2059189..2092207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086234.2 → XP_038942162.1  bifunctional apoptosis regulator isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y9Y1
    Related
    ENSRNOP00000078143.1
    Conserved Domains (2) summary
    cd16497
    Location:32 → 77
    RING-HC_BAR; RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)
    cl15755
    Location:98 → 124
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_063269266.1 → XP_063125336.1  bifunctional apoptosis regulator isoform X1

    UniProtKB/Swiss-Prot
    Q5PQN2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQN2.1 GenPept UniProtKB/Swiss-Prot:Q5PQN2

Gene LinkOut

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