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Rnf17 ring finger protein 17 [ Mus musculus (house mouse) ]

Gene ID: 30054, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf17provided by MGI
Official Full Name
ring finger protein 17provided by MGI
Primary source
MGI:MGI:1353419
See related
Ensembl:ENSMUSG00000000365 AllianceGenome:MGI:1353419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mmip2; TDRD4; MMIP-2
Summary
Enables identical protein binding activity. Acts upstream of or within spermatid development. Located in cytoplasm. Is expressed in bladder; ovary; testis; and ureter. Orthologous to human RNF17 (ring finger protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.8) and placenta adult (RPKM 0.9) See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.21 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56640107..56762489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56402650..56525032)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+/K+ transporting, nongastric, alpha polypeptide Neighboring gene STARR-seq mESC enhancer starr_36795 Neighboring gene predicted gene, 32454 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene centromere protein J Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network. Yin XY, et al. Oncogene, 1999 Nov 18. PMID 10597267
  2. ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis. Xiong M, et al. J Cell Biol, 2023 May 1. PMID 36930220, Free PMC Article
  3. RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Wasik KA, et al. Genes Dev, 2015 Jul 1. PMID 26115953, Free PMC Article
  4. RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Pan J, et al. Development, 2005 Sep. PMID 16093322, Free PMC Article
  5. Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression. Vasileva A, et al. Curr Biol, 2009 Apr 28. PMID 19345099, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
    Title: Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
  2. RNF17 shapes adult meiotic piRNA content by suppressing the production of secondary piRNAs
    Title: RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.
  3. RNF17 is a component of a novel germ cell nuage and is required for differentiation of male germ cells.
    Title: RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
  4. RNF17 is required for spermiogenesis in mouse. There are two RNF17 protein isoforms: RNF17L and RNF17S. RNF17 localizes to a novel nuage in germ cells.
    Title: RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 17
Names
Max dimerization protein member-interacting protein 2
mad member-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033043.1 → NP_001028215.1  RING finger protein 17

    See identical proteins and their annotated locations for NP_001028215.1

    Status: PROVISIONAL

    Source sequence(s)
    AY854011
    Consensus CDS
    CCDS27149.1
    UniProtKB/Swiss-Prot
    Q3T4H2, Q3T4H3, Q4FZG6, Q8CDR4, Q99MV7, Q9QXQ2
    Related
    ENSMUSP00000093469.2, ENSMUST00000095793.3
    Conserved Domains (3) summary
    cd04508
    Location:755 → 801
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:1196 → 1312
    TUDOR; Tudor domain
    cl23765
    Location:158 → 242
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56640107..56762489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519108.3 → XP_006519171.1  RING finger protein 17 isoform X1

    Conserved Domains (2) summary
    smart00502
    Location:158 → 242
    BBC; B-Box C-terminal domain
    pfam00567
    Location:706 → 819
    TUDOR; Tudor domain

  2. XM_006519109.3 → XP_006519172.1  RING finger protein 17 isoform X2

    Conserved Domains (3) summary
    smart00502
    Location:158 → 242
    BBC; B-Box C-terminal domain
    PRK03918
    Location:87 → 273
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam00567
    Location:706 → 819
    TUDOR; Tudor domain

  3. XM_006519110.4 → XP_006519173.1  RING finger protein 17 isoform X4

    See identical proteins and their annotated locations for XP_006519173.1

    UniProtKB/Swiss-Prot
    Q99MV7
    Conserved Domains (2) summary
    smart00502
    Location:158 → 242
    BBC; B-Box C-terminal domain
    pfam00567
    Location:706 → 819
    TUDOR; Tudor domain

  4. XM_030247856.1 → XP_030103716.1  RING finger protein 17 isoform X3

    Conserved Domains (1) summary
    pfam00567
    Location:730 → 840
    TUDOR; Tudor domain

  5. XM_030247854.1 → XP_030103714.1  RING finger protein 17 isoform X3

    Conserved Domains (1) summary
    pfam00567
    Location:730 → 840
    TUDOR; Tudor domain

  6. XM_006519112.1 → XP_006519175.1  RING finger protein 17 isoform X5

    UniProtKB/Swiss-Prot
    Q99MV7
    Conserved Domains (1) summary
    pfam00567
    Location:622 → 732
    TUDOR; Tudor domain

  7. XM_030247855.1 → XP_030103715.1  RING finger protein 17 isoform X3

    Conserved Domains (1) summary
    pfam00567
    Location:730 → 840
    TUDOR; Tudor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MV7.2 GenPept UniProtKB/Swiss-Prot:Q99MV7

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