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Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 [ Mus musculus (house mouse) ]

Gene ID: 30045, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc12provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C12provided by MGI
Primary source
MGI:MGI:1353428
See related
Ensembl:ENSMUSG00000036764 AllianceGenome:MGI:1353428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jdp1; mJDP1
Summary
Predicted to be located in cytoplasm. Is expressed in brain; gut; and liver lobe. Orthologous to human DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 26.8), cerebellum adult (RPKM 7.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63218222..63244619)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63382443..63408840)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hect domain and RLD 4 Neighboring gene predicted gene, 51767 Neighboring gene sirtuin 1 Neighboring gene Sirt1 promoter region Neighboring gene STARR-seq mESC enhancer starr_26931 Neighboring gene STARR-seq mESC enhancer starr_26932 Neighboring gene STARR-positive B cell enhancer ABC_E5142 Neighboring gene calcyclin binding protein pseudogene Neighboring gene ring finger protein 7 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural analysis of phylogenetically conserved J domain protein gene. Hahn Y, et al. Biochim Biophys Acta, 1999 Oct 28. PMID 10542335
  2. Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths. Lee J, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760603
  3. Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Chatterjee S, et al. Proc Natl Acad Sci U S A, 2019 Dec 26. PMID 31818953, Free PMC Article
  4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 12
Names
DnaJ (Hsp40) homolog, subfamily C, member 12
J domain protein 1
j domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253685.1 → NP_001240614.1  dnaJ homolog subfamily C member 12 isoform 2

    See identical proteins and their annotated locations for NP_001240614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK002649, BF453706, BM899037
    UniProtKB/TrEMBL
    D3Z0D9, Q9CWA0
    Related
    ENSMUSP00000120892.2, ENSMUST00000129625.8

  2. NM_013888.3 → NP_038916.1  dnaJ homolog subfamily C member 12 isoform 1

    See identical proteins and their annotated locations for NP_038916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153516, AC164179, AK002649, BM899037, DV042983
    Consensus CDS
    CCDS23899.1
    UniProtKB/Swiss-Prot
    Q9R022
    Related
    ENSMUSP00000041298.6, ENSMUST00000043317.7
    Conserved Domains (1) summary
    pfam00226
    Location:14 → 76
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63218222..63244619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R022.1 GenPept UniProtKB/Swiss-Prot:Q9R022

Gene LinkOut

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