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IL19 interleukin 19 [ Homo sapiens (human) ]

Gene ID: 29949, updated on 10-Dec-2024

Summary

Official Symbol
IL19provided by HGNC
Official Full Name
interleukin 19provided by HGNC
Primary source
HGNC:HGNC:5990
See related
Ensembl:ENSG00000142224 MIM:605687; AllianceGenome:HGNC:5990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDA1; NG.1; ZMDA1; IL-10C
Summary
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL19 in Genome Data Viewer
Location:
1q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206770773..206842981)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206034974..206107261)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206944118..207016326)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904496 Neighboring gene uncharacterized LOC124904495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1764 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206860855-206861416 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206861417-206861978 Neighboring gene MAPK activated protein kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2412 Neighboring gene Sharpr-MPRA regulatory region 3087 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206895773-206896486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2417 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:206937123-206937321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene interleukin 10 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 20 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat IL-19 is upregulated in human epithelial cells by HIV-1 Tat treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in extracellular region PubMed 
located_in extracellular region  
located_in extracellular space  

General protein information

Preferred Names
interleukin-19
Names
melanoma differentiation associated protein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369605.1NP_001356534.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AF453946, AL513315, AY040367, CA309757
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
    Related
    ENSP00000343000.3, ENST00000340758.7
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  2. NM_001393490.1NP_001380419.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
    Related
    ENSP00000499487.2, ENST00000656872.2
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  3. NM_001393491.1NP_001380420.1  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  4. NM_013371.5NP_037503.2  interleukin-19 precursor

    See identical proteins and their annotated locations for NP_037503.2

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
    Related
    ENSP00000270218.6, ENST00000270218.10
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10
  5. NM_153758.5NP_715639.2  interleukin-19 precursor

    Status: REVIEWED

    Source sequence(s)
    AL513315
    Consensus CDS
    CCDS1469.1
    UniProtKB/Swiss-Prot
    B6VEV9, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0
    Related
    ENSP00000499459.2, ENST00000659997.3
    Conserved Domains (1) summary
    cl02501
    Location:21167
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206770773..206842981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509450.3XP_011507752.1  interleukin-19 isoform X1

    See identical proteins and their annotated locations for XP_011507752.1

    UniProtKB/Swiss-Prot
    Q9UHD0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206034974..206107261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336198.1XP_054192173.1  interleukin-19 isoform X1

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