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CCDC106 coiled-coil domain containing 106 [ Homo sapiens (human) ]

Gene ID: 29903, updated on 5-Mar-2024

Summary

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Official Symbol
CCDC106provided by HGNC
Official Full Name
coiled-coil domain containing 106provided by HGNC
Primary source
HGNC:HGNC:30181
See related
Ensembl:ENSG00000173581 MIM:613478; AllianceGenome:HGNC:30181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF581; HSU79303
Summary
Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 7.5), brain (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55647400..55653161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58743329..58749089)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56158766..56164527)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107983998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15101 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:56146823-56146990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11051 Neighboring gene zinc finger protein 581 Neighboring gene Sharpr-MPRA regulatory region 1979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56155949-56156914 Neighboring gene zinc finger protein 580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15107 Neighboring gene U2 small nuclear RNA auxiliary factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11061 Neighboring gene Sharpr-MPRA regulatory region 14549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56192159-56192659 Neighboring gene epsin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56213120-56214004 Neighboring gene vomeronasal 1 receptor 106 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing. Zhi W, et al. J Med Virol, 2023 Jan. PMID 35854676, Free PMC Article
  2. CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway. Zhao N, et al. Bioengineered, 2022 Apr. PMID 35484984, Free PMC Article
  3. CCDC106 promotes non-small cell lung cancer cell proliferation. Zhang X, et al. Oncotarget, 2017 Apr 18. PMID 28460455, Free PMC Article
  4. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer. Cao C, et al. J Genet Genomics, 2020 Aug. PMID 33023834
  5. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. Zhou J, et al. FEBS Lett, 2010 Mar 19. PMID 20159018

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
    Title: HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
  2. CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
    Title: CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
  3. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
    Title: HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
  4. Study revealed a CK2/CCDC106/p53 signaling axis in the progression of breast and cervical cancers.
    Title: CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression.
  5. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment.
    Title: CCDC106 promotes non-small cell lung cancer cell proliferation.
  6. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity.
    Title: Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 106
Names
protein predicted by clone 23882

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370467.1 → NP_001357396.1  coiled-coil domain-containing protein 106 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008735, GU354321
    Consensus CDS
    CCDS33118.1
    UniProtKB/Swiss-Prot
    B3KUF9, D3K183, Q99786, Q9BWC9
    Conserved Domains (1) summary
    pfam15794
    Location:55 → 276
    CCDC106; Coiled-coil domain-containing protein 106

  2. NM_001370468.1 → NP_001357397.1  coiled-coil domain-containing protein 106 isoform 1

    Status: VALIDATED

    Source sequence(s)
    DA360854, GU354322
    Consensus CDS
    CCDS33118.1
    UniProtKB/Swiss-Prot
    B3KUF9, D3K183, Q99786, Q9BWC9
    Related
    ENSP00000468539.1, ENST00000588740.5
    Conserved Domains (1) summary
    pfam15794
    Location:55 → 276
    CCDC106; Coiled-coil domain-containing protein 106

  3. NM_001370469.1 → NP_001357398.1  coiled-coil domain-containing protein 106 isoform 1

    Status: VALIDATED

    Source sequence(s)
    DA360854, GU354323
    Consensus CDS
    CCDS33118.1
    UniProtKB/Swiss-Prot
    B3KUF9, D3K183, Q99786, Q9BWC9
    Related
    ENSP00000466870.1, ENST00000591578.5
    Conserved Domains (1) summary
    pfam15794
    Location:55 → 276
    CCDC106; Coiled-coil domain-containing protein 106

  4. NM_001370470.1 → NP_001357399.1  coiled-coil domain-containing protein 106 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008735, BI755544, GU354323
    Consensus CDS
    CCDS33118.1
    UniProtKB/Swiss-Prot
    B3KUF9, D3K183, Q99786, Q9BWC9
    Related
    ENSP00000465757.1, ENST00000586790.6
    Conserved Domains (1) summary
    pfam15794
    Location:55 → 276
    CCDC106; Coiled-coil domain-containing protein 106

  5. NM_001370471.1 → NP_001357400.1  coiled-coil domain-containing protein 106 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008735
    Consensus CDS
    CCDS92692.1
    UniProtKB/TrEMBL
    K7EMI9
    Related
    ENSP00000466521.1, ENST00000591241.1
    Conserved Domains (1) summary
    pfam15794
    Location:20 → 241
    CCDC106; Coiled-coil domain-containing protein 106

  6. NM_013301.2 → NP_037433.2  coiled-coil domain-containing protein 106 isoform 1

    See identical proteins and their annotated locations for NP_037433.2

    Status: VALIDATED

    Source sequence(s)
    AC008735, AF054984, BI907663
    Consensus CDS
    CCDS33118.1
    UniProtKB/Swiss-Prot
    B3KUF9, D3K183, Q99786, Q9BWC9
    Related
    ENSP00000309681.2, ENST00000308964.7
    Conserved Domains (1) summary
    pfam15794
    Location:55 → 276
    CCDC106; Coiled-coil domain-containing protein 106

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55647400..55653161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58743329..58749089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWC9.1 GenPept UniProtKB/Swiss-Prot:Q9BWC9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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