CNOT7 CCR4-NOT transcription complex subunit 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNOT7provided by HGNC
Official Full Name: CCR4-NOT transcription complex subunit 7provided by HGNC
Primary source: HGNC:HGNC:14101
See related: Ensembl:ENSG00000198791 MIM:604913; AllianceGenome:HGNC:14101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAF1; CAF-1; Caf1a; hCAF-1
Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
Expression: Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (17224966..17246857, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (17492557..17514454, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (17082475..17104366, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.
Title: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.
Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
Title: Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.
Title: CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
Title: Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.
Title: CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.
Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 (CNOT7) deadenylation activity.
Title: DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.
Active 1-hydroxy-xanthines inhibit both isolated Caf1 (CNOT7) enzyme and human Caf1-containing complexes that also contain the second nuclease subunit Ccr4 (CNOT6L) to a similar extent, indicating that the active site of the Caf1 nuclease subunit does not undergo substantial conformational change when bound to other Ccr4-Not subunits.
Title: 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.
Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover
Title: Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7.
Title: A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC.
Title: CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2081 (e-PCR)
- UniSTS:9028

D8S1343E (e-PCR)
- UniSTS:57715

CNOT7_1517 (e-PCR)
- UniSTS:277109

PMC310830P26 (e-PCR)
- UniSTS:272769

RH80037 (e-PCR)
- UniSTS:84141

CNOT7 (e-PCR)
- UniSTS:278215

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IEA Inferred from Electronic Annotation more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IDA Inferred from Direct Assay more info	PubMed
part_of CCR4-NOT complex	NAS Non-traceable Author Statement more info	PubMed
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in intracellular non-membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nuclear speck	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 7

Names: BTG1-binding factor 1; CCR4-associated factor 1; carbon catabolite repressor protein (CCR4)-associative factor 1

NP_001309016.1

EC 3.1.13.4

NP_001309017.1

EC 3.1.13.4

NP_001309018.1

EC 3.1.13.4

NP_001309019.1

EC 3.1.13.4

NP_001309020.1

EC 3.1.13.4

NP_001309021.1

EC 3.1.13.4

NP_001309022.1

EC 3.1.13.4

NP_001309023.1

EC 3.1.13.4

NP_001309024.1

EC 3.1.13.4

NP_001309025.1

EC 3.1.13.4

NP_001309026.1

EC 3.1.13.4

NP_001309027.1

EC 3.1.13.4

NP_001309028.1

EC 3.1.13.4

NP_001309029.1

EC 3.1.13.4

NP_037486.2

EC 3.1.13.4

NP_473367.2

EC 3.1.13.4

XP_005273538.1

EC 3.1.13.4

XP_047277685.1

EC 3.1.13.4

XP_047277686.1

EC 3.1.13.4

XP_047277687.1

EC 3.1.13.4

XP_054216351.1

EC 3.1.13.4

XP_054216352.1

EC 3.1.13.4

XP_054216353.1

EC 3.1.13.4

XP_054216354.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001322087.2 → NP_001309016.1 CCR4-NOT transcription complex subunit 7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.

Source sequence(s)

AW448990, BC070187, BI094365, BI458088, DA695885, DA752620

Consensus CDS

CCDS55202.1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:1 → 244

CAF1; CAF1 family ribonuclease
NM_001322088.2 → NP_001309017.1 CCR4-NOT transcription complex subunit 7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.

Source sequence(s)

AL833642, AW448990, BC070187, BI094365, DA695885

Consensus CDS

CCDS55202.1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:1 → 244

CAF1; CAF1 family ribonuclease
NM_001322089.2 → NP_001309018.1 CCR4-NOT transcription complex subunit 7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.

Source sequence(s)

AC091050, AW448990, BC070187, BI094365, BI464507, DA695885, HY002876

Consensus CDS

CCDS55202.1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:1 → 244

CAF1; CAF1 family ribonuclease
NM_001322090.2 → NP_001309019.1 CCR4-NOT transcription complex subunit 7 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.

Source sequence(s)

AC091050, BC007315, BC070187, BI458088, DA752620

Consensus CDS

CCDS6000.2

UniProtKB/Swiss-Prot

A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

UniProtKB/TrEMBL

B3KM57

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_001322091.2 → NP_001309020.1 CCR4-NOT transcription complex subunit 7 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.

Source sequence(s)

AC091050, AL833642, BC007315, BC070187

Consensus CDS

CCDS6000.2

UniProtKB/Swiss-Prot

A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

UniProtKB/TrEMBL

B3KM57

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_001322092.2 → NP_001309021.1 CCR4-NOT transcription complex subunit 7 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.

Source sequence(s)

AC091050, AL833642, BC007315, BC070187, BI458088

Consensus CDS

CCDS6000.2

UniProtKB/Swiss-Prot

A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

UniProtKB/TrEMBL

B3KM57

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_001322093.2 → NP_001309022.1 CCR4-NOT transcription complex subunit 7 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.

Source sequence(s)

AC091050, BC007315, BC070187, BI464507, DA752620

UniProtKB/TrEMBL

B3KM57

Conserved Domains (1) summary

cl23804
Location:1 → 301

CAF1; CAF1 family ribonuclease
NM_001322094.2 → NP_001309023.1 CCR4-NOT transcription complex subunit 7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate splice site in the 3' terminal exon and thus contains an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AL528251, BC007315, BC070187, DA752620

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:1 → 245

CAF1; CAF1 family ribonuclease
NM_001322095.2 → NP_001309024.1 CCR4-NOT transcription complex subunit 7 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (11) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.

Source sequence(s)

AC091050, BC007315, BC070187, DA508565, DA752620

UniProtKB/Swiss-Prot

Q9UIV1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:2 → 198

CAF1; CAF1 family ribonuclease
NM_001322096.2 → NP_001309025.1 CCR4-NOT transcription complex subunit 7 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (12) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.

Source sequence(s)

AC091050, BC007315, BC070187, DA720240, DA752620

UniProtKB/Swiss-Prot

Q9UIV1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:2 → 198

CAF1; CAF1 family ribonuclease
NM_001322097.2 → NP_001309026.1 CCR4-NOT transcription complex subunit 7 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.

Source sequence(s)

AC091050, AL833642, BC007315, BC070187, DA720240

UniProtKB/Swiss-Prot

Q9UIV1

UniProtKB/TrEMBL

Q96IQ6

Conserved Domains (1) summary

cl23804
Location:2 → 198

CAF1; CAF1 family ribonuclease
NM_001322098.2 → NP_001309027.1 CCR4-NOT transcription complex subunit 7 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (14) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.

Source sequence(s)

AW448990, BC070187, BI094365, DA508565, DA695885, DA752620

UniProtKB/Swiss-Prot

Q9UIV1

Conserved Domains (1) summary

cl23804
Location:2 → 163

CAF1; CAF1 family ribonuclease
NM_001322099.2 → NP_001309028.1 CCR4-NOT transcription complex subunit 7 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (15) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.

Source sequence(s)

AW448990, BC070187, BI094365, DA695885, DA720240, DA752620

UniProtKB/Swiss-Prot

Q9UIV1

Conserved Domains (1) summary

cl23804
Location:2 → 163

CAF1; CAF1 family ribonuclease
NM_001322100.2 → NP_001309029.1 CCR4-NOT transcription complex subunit 7 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (16) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.

Source sequence(s)

AW448990, BC070187, BI094365, BI458088, DA508565, DA695885

UniProtKB/Swiss-Prot

Q9UIV1

Conserved Domains (1) summary

cl23804
Location:2 → 163

CAF1; CAF1 family ribonuclease
NM_013354.7 → NP_037486.2 CCR4-NOT transcription complex subunit 7 isoform 1

See identical proteins and their annotated locations for NP_037486.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, 7 and 8 all encode isoform 1.

Source sequence(s)

AC091050, BC007315, BC070187, DA752620

Consensus CDS

CCDS6000.2

UniProtKB/Swiss-Prot

A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

UniProtKB/TrEMBL

B3KM57

Related

ENSP00000355279.4, ENST00000361272.9

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_054026.4 → NP_473367.2 CCR4-NOT transcription complex subunit 7 isoform 2

See identical proteins and their annotated locations for NP_473367.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.

Source sequence(s)

AW448990, BC070187, BI094365, DA695885, DA752620

Consensus CDS

CCDS55202.1

UniProtKB/TrEMBL

Q96IQ6

Related

ENSP00000429093.1, ENST00000523917.5

Conserved Domains (1) summary

cl23804
Location:1 → 244

CAF1; CAF1 family ribonuclease