Iqgap1 IQ motif containing GTPase activating protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iqgap1provided by MGI
Official Full Name: IQ motif containing GTPase activating protein 1provided by MGI
Primary source: MGI:MGI:1352757
See related: Ensembl:ENSMUSG00000030536 AllianceGenome:MGI:1352757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0051; D7Ertd237e; D7Ertd257e
Summary: Enables small GTPase binding activity. Involved in cellular response to growth factor stimulus; positive regulation of protein kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within fibroblast migration; negative regulation of dephosphorylation; and regulation of cytokine production. Located in several cellular components, including cortical actin cytoskeleton; focal adhesion; and lateral plasma membrane. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 47.3), spleen adult (RPKM 27.7) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 D3; 7 45.68 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80361331..80453288, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80711583..80815549, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels.
Title: IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels.
IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation.
Title: IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation.
Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.
Title: Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.
IQGAP1/ERK regulates fear memory formation via histone posttranslational modifications induced by HDAC2.
Title: IQGAP1/ERK regulates fear memory formation via histone posttranslational modifications induced by HDAC2.
Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
Title: Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s.
Title: IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s.
these results implicate IQGAP1 as an essential scaffold for NK cell homeostasis and function and provide novel mechanistic insights to the post-transcriptional regulation of inflammatory cytokine production.
Title: IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.
over-expression of IQGAP1 in human head and neck squamous cell carcinoma may indicate poor prognosis.
Title: Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.
Alterations in IQGAP1 signalling promote the emergence of cancer stem cells and gastric adenocarcinoma development in the context of an H. pylori infection.
Title: Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH126623 (e-PCR)
- UniSTS:167505

RH126723 (e-PCR)
- UniSTS:167506

RH125610 (e-PCR)
- UniSTS:162424

C79170 (e-PCR)
- UniSTS:159656

Iqgap1 (e-PCR), detects polymorphism
- UniSTS:256440

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IGI Inferred from Genetic Interaction more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IGI Inferred from Genetic Interaction more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IGI Inferred from Genetic Interaction more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ras GTPase-activating-like protein IQGAP1

Names: Cdc42-Rac1 effector protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016721.2 → NP_057930.2 ras GTPase-activating-like protein IQGAP1

See identical proteins and their annotated locations for NP_057930.2

Status: VALIDATED

Source sequence(s)

AK160892, AK164482, BQ174517, BY107028, CB519254, DV069947

Consensus CDS

CCDS40001.1

UniProtKB/Swiss-Prot

G3UW45, Q9JKF1

UniProtKB/TrEMBL

Q80UW7

Related

ENSMUSP00000128278.2, ENSMUST00000167377.3

Conserved Domains (6) summary

smart00015
Location:774 → 796

IQ; Calmodulin-binding motif

cd05133
Location:1003 → 1382

RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1

smart00323
Location:992 → 1344

RasGAP; GTPase-activator protein for Ras-like GTPases

cd00014
Location:45 → 159

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00201
Location:685 → 712

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam03836
Location:1452 → 1580

RasGAP_C; RasGAP C-terminus