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Plekhn1 pleckstrin homology domain containing N1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298694, updated on 5-Mar-2024

Summary

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Official Symbol
Plekhn1provided by RGD
Official Full Name
pleckstrin homology domain containing N1provided by RGD
Primary source
RGD:1311019
See related
Ensembl:ENSRNOG00000020295 AllianceGenome:RGD:1311019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311019
Summary
Predicted to enable phospholipid binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Predicted to be located in mitochondrion. Predicted to be active in cytoskeleton and mitochondrial membrane. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 37.2), Lung (RPKM 23.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (172087524..172095566, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166805309..166813339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173646055..173654140, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene agrin Neighboring gene ISG15 ubiquitin-like modifier Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene kelch-like family member 17 Neighboring gene NOC2-like nucleolar associated transcriptional repressor Neighboring gene sterile alpha motif domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of N-myristoylation in stability and subcellular localization of the CLPABP protein. Maeda A, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29180010
  2. Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. Sano E, et al. Biochim Biophys Acta, 2008 Jun. PMID 18191643
  3. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Nishino T, et al. Biochim Biophys Acta, 2016 Nov. PMID 27616329
  4. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Kuriyama S, et al. Cell Death Discov, 2018 Dec. PMID 29531808, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cardiolipin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family N member 1
Names
pleckstrin homology domain containing, family N member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134523.1 → NP_001127995.1  pleckstrin homology domain-containing family N member 1

    See identical proteins and their annotated locations for NP_001127995.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6IUW8, D3Z815
    Related
    ENSRNOP00000031799.4, ENSRNOT00000038556.5
    Conserved Domains (2) summary
    cd13323
    Location:222 → 341
    PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
    cl17171
    Location:96 → 188
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    172087524..172095566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239565.5 → XP_006239627.1  pleckstrin homology domain-containing family N member 1 isoform X2

    See identical proteins and their annotated locations for XP_006239627.1

    UniProtKB/TrEMBL
    A6IUW9
    Conserved Domains (2) summary
    cd13323
    Location:222 → 341
    PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
    cl17171
    Location:96 → 188
    PH-like; Pleckstrin homology-like domain

  2. XM_006239564.5 → XP_006239626.1  pleckstrin homology domain-containing family N member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUH3
    Related
    ENSRNOP00000082942.1
    Conserved Domains (2) summary
    cd13323
    Location:222 → 341
    PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
    cl17171
    Location:96 → 188
    PH-like; Pleckstrin homology-like domain

  3. XM_063287515.1 → XP_063143585.1  pleckstrin homology domain-containing family N member 1 isoform X4

  4. XM_039109730.2 → XP_038965658.1  pleckstrin homology domain-containing family N member 1 isoform X3

    Conserved Domains (1) summary
    cd13323
    Location:34 → 153
    PH_PLEKHN1; Pleckstrin homology domain containing family N member 1Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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