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Ulk2 unc-51 like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 29869, updated on 11-Apr-2024

Summary

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Official Symbol
Ulk2provided by MGI
Official Full Name
unc-51 like kinase 2provided by MGI
Primary source
MGI:MGI:1352758
See related
Ensembl:ENSMUSG00000004798 AllianceGenome:MGI:1352758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc51.2; mKIAA0623; A830085I22Rik
Summary
Enables protein serine/threonine kinase activity. Involved in autophagy and response to starvation. Acts upstream of or within axon extension and negative regulation of collateral sprouting. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.96 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61666424..61750754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61775598..61855334, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene A kinase anchor protein 10 Neighboring gene STARR-seq mESC enhancer starr_29689 Neighboring gene STARR-positive B cell enhancer ABC_E8413 Neighboring gene predicted gene, 23721

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle. Fuqua JD, et al. FASEB J, 2019 Nov. PMID 31361156, Free PMC Article
  2. Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle. Drake JC, et al. Front Physiol, 2021. PMID 34658916, Free PMC Article
  3. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Sumitomo A, et al. Hum Mol Genet, 2018 Sep 15. PMID 29893844, Free PMC Article
  4. Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth. Shukla S, et al. J Biol Chem, 2014 Aug 8. PMID 24923441, Free PMC Article
  5. Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes. Ro SH, et al. Autophagy, 2013 Dec. PMID 24135897, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.
    Title: Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.
  2. that skeletal muscle ULK2 has a unique role in basal selective protein degradation by stimulating the recognition and proteolytic sequestration of insoluble ubiquitinated protein aggregates
    Title: ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle.
  3. we demonstrate that disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions; this myopathy is similar to that caused by VCP/p97 mutations, the most common cause of familial inclusion body myopathy (IBM)
    Title: ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
  4. ULK1 and ULK2 regulate axon guidance during mammalian brain development via a noncanonical (i.e., autophagy-independent) pathway.
    Title: The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.
  5. Here we show that Ulk2 heterozygous (Ulk2+/-) mice have upregulated expression of sequestosome-1/p62, an autophagy-associated stress response protein, predominantly in pyramidal neurons of the prefrontal cortex (PFC), and exhibit behavioral deficits associated with the PFC functions, including attenuated sensorimotor gating and impaired cognition
    Title: Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.
  6. Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis.
    Title: The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.
  7. ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.
    Title: ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
  8. autophagy can be executed by mechanisms that are dependent or independent of the ULK1/2-ATG13 interaction.
    Title: Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
  9. AnxA2 regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1-mTOR-ULK1/2 signaling pathway
    Title: Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway.
  10. ULK2 induced autophagy and inhibited growth in Ras-transformed immortalized Baby Mouse Kidney (iBMK) ATG5(+/+) but not in autophagy-deficient ATG5(-/-) cells.
    Title: Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatic sensory system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK2
Names
serine/threonine-protein kinase Unc51.2
NP_038909.3
XP_006533571.1
XP_006533572.1
XP_030101926.1
XP_036012644.1
XP_036012645.1
XP_036012646.1
XP_036012647.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013881.4 → NP_038909.3  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_038909.3

    Status: VALIDATED

    Source sequence(s)
    AK146620, AK148142, AV256860, BM124275
    Consensus CDS
    CCDS24820.1
    UniProtKB/Swiss-Prot
    Q80TV7, Q9QY01, Q9WTP4
    UniProtKB/TrEMBL
    Q3UG39
    Related
    ENSMUSP00000004920.4, ENSMUST00000004920.4
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:865 → 1030
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61666424..61750754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156753.1 → XP_036012646.1  serine/threonine-protein kinase ULK2 isoform X6

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:725 → 912
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1 → 154
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036156752.1 → XP_036012645.1  serine/threonine-protein kinase ULK2 isoform X5

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:725 → 904
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1 → 154
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036156751.1 → XP_036012644.1  serine/threonine-protein kinase ULK2 isoform X2

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:809 → 988
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:2 → 238
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030246066.2 → XP_030101926.1  serine/threonine-protein kinase ULK2 isoform X4

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802 → 984
    DUF3543; Domain of unknown function (DUF3543)

  5. XM_006533509.5 → XP_006533572.1  serine/threonine-protein kinase ULK2 isoform X3

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802 → 973
    DUF3543; Domain of unknown function (DUF3543)

  6. XM_036156754.1 → XP_036012647.1  serine/threonine-protein kinase ULK2 isoform X7

    Conserved Domains (1) summary
    pfam12063
    Location:367 → 546
    DUF3543; Domain of unknown function (DUF3543)

  7. XM_006533508.5 → XP_006533571.1  serine/threonine-protein kinase ULK2 isoform X1

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:848 → 1019
    DUF3543; Domain of unknown function (DUF3543)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QY01.1 GenPept UniProtKB/Swiss-Prot:Q9QY01

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