U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Igfbp7 insulin-like growth factor binding protein 7 [ Mus musculus (house mouse) ]

Gene ID: 29817, updated on 18-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Igfbp7provided by MGI
Official Full Name
insulin-like growth factor binding protein 7provided by MGI
Primary source
MGI:MGI:1352480
See related
Ensembl:ENSMUSG00000036256 AllianceGenome:MGI:1352480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AGM; Fstl2; Mac25
Summary
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 2884.8), ovary adult (RPKM 2858.2) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 C3.3; 5 41.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77497092..77555892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77349240..77408045, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:77704983-77705284 Neighboring gene microRNA 5098 Neighboring gene RE1-silencing transcription factor Neighboring gene STARR-seq mESC enhancer starr_13474 Neighboring gene nitric oxide associated 1 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene predicted gene, 34648 Neighboring gene STARR-seq mESC enhancer starr_13478 Neighboring gene predicted gene, 34728 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:77889021-77889208 Neighboring gene STARR-positive B cell enhancer ABC_E6341 Neighboring gene RIKEN cDNA 1700017L05 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation. Yu JT, et al. Kidney Int, 2022 Oct. PMID 35752325
  2. Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis. Zhang H, et al. Sci Transl Med, 2021 Oct 6. PMID 34613814
  3. IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway. Xu Q, et al. Folia Histochem Cytobiol, 2020. PMID 33326113
  4. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Akiel M, et al. Cancer Res, 2017 Aug 1. PMID 28619711, Free PMC Article
  5. Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression. Liao Y, et al. Mol Ther, 2016 Oct. PMID 27397633, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural insight into CD93 recognition by IGFBP7.
    Title: Structural insight into CD93 recognition by IGFBP7.
  2. METTL3-mediated m[6]A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
    Title: METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
  3. Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.
    Title: Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.
  4. IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway.
    Title: IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway.
  5. Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
    Title: Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
  6. The mechanism may be that eleutheroside B can activate the insulin-like growth factor (IGF) pathway and its downstream pathway by downregulating the expression of IGFBP-7, thus promoting cell proliferation. Therefore, our results suggest that eleutheroside B is a potential drug for Acute kidney injury (AKI) treatment.
    Title: Eleutheroside B Protects against Acute Kidney Injury by Activating IGF Pathway.
  7. IGFBP7 inhibited receptor activation of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclastogenesis.
    Title: IGFBP7 acts as a negative regulator of RANKL-induced osteoclastogenesis and oestrogen deficiency-induced bone loss.
  8. IGFBP7 has a role in regulating sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling
    Title: IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
  9. IGFBPrP1 promoted autophagy and contributed to hepatic stellate cell activation via mutual regulation between H19 and the PI3K/AKT/mTOR pathway.
    Title: IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway.
  10. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma
    Title: IGFBP7 Deletion Promotes Hepatocellular Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
insulin-like growth factor-binding protein 7
Names
IBP-7
IGF-binding protein 7
IGFBP-7
angiomodulin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159518.2 → NP_001152990.2  insulin-like growth factor-binding protein 7 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122396, AC141469
    Consensus CDS
    CCDS51530.1
    UniProtKB/TrEMBL
    E9Q5D9, F8WH23
    Related
    ENSMUSP00000128318.3, ENSMUST00000163898.6
    Conserved Domains (3) summary
    smart00121
    Location:31 → 89
    IB; Insulin growth factor-binding protein homologues
    smart00280
    Location:110 → 155
    KAZAL; Kazal type serine protease inhibitors
    smart00409
    Location:204 → 295
    IG; Immunoglobulin

  2. NM_008048.4 → NP_032074.4  insulin-like growth factor-binding protein 7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC122396, AC141469
    Consensus CDS
    CCDS51529.1
    UniProtKB/Swiss-Prot
    O88812, Q61581, Q9EQW0
    UniProtKB/TrEMBL
    F8WH23
    Related
    ENSMUSP00000045057.8, ENSMUST00000046746.10
    Conserved Domains (4) summary
    smart00121
    Location:31 → 89
    IB; Insulin growth factor-binding protein homologues
    smart00280
    Location:110 → 155
    KAZAL; Kazal type serine protease inhibitors
    cd00096
    Location:174 → 183
    Ig; Ig strand B [structural motif]
    cl11960
    Location:159 → 264
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77497092..77555892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61581.3 GenPept UniProtKB/Swiss-Prot:Q61581

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous