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Ndrg3 N-myc downstream regulated gene 3 [ Mus musculus (house mouse) ]

Gene ID: 29812, updated on 21-Apr-2024

Summary

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Official Symbol
Ndrg3provided by MGI
Official Full Name
N-myc downstream regulated gene 3provided by MGI
Primary source
MGI:MGI:1352499
See related
Ensembl:ENSMUSG00000027634 AllianceGenome:MGI:1352499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr3; 4833415O14Rik
Summary
Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb interdigital region mesenchyme; genitourinary system; and thymus primordium. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 162.3), cortex adult (RPKM 113.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.89 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156769262..156834052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156927342..156992132, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06191 Neighboring gene STARR-seq mESC enhancer starr_06192 Neighboring gene N-myc downstream regulated gene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06193 Neighboring gene STARR-positive B cell enhancer ABC_E4513 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers. Sohn HA, et al. Cells, 2022 May 4. PMID 35563842, Free PMC Article
  2. Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization. Yang Q, et al. Reprod Sci, 2018 Aug. PMID 29096585
  3. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. Xu Y, et al. J Biol Chem, 2023 Jun. PMID 37172727, Free PMC Article
  4. Cloning and expression pattern of the human NDRG3 gene. Zhao W, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406283
  5. Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells. Pan H, et al. Sci Rep, 2017 Mar 14. PMID 28290521, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
    Title: Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
  2. we reported that Ndrg3 gene modulated the lactate induced ERK pathway to facilitate DSB repair in male germ cells, which further regulated meiosis and subsequently fertility in male mouse.
    Title: Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells.
  3. Data suggested that n-myc downstream-regulated gene 3 might play an important role in embryo implantation by regulating decidualization potentially via the estrogen/progesterone/miR-290b-5p pathway.
    Title: Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization.
  4. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.
    Title: Differential expression patterns of NDRG family proteins in the central nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in decidualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
protein NDRG3
Names
N-myc downstream regulated 3
N-myc downstream-regulated gene 3 protein
protein Ndr3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355391.1 → NP_001342320.1  protein NDRG3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL669932, AL935150
    Consensus CDS
    CCDS50780.1
    UniProtKB/TrEMBL
    Q8VCV2
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  2. NM_001355392.1 → NP_001342321.1  protein NDRG3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AL669932, AL935150
    Consensus CDS
    CCDS16971.1
    UniProtKB/Swiss-Prot
    Q9QYF9
    UniProtKB/TrEMBL
    Q544I1
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  3. NM_001355393.1 → NP_001342322.1  protein NDRG3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' end compared to variant 3. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform (1).
    Source sequence(s)
    AL669932, AL935150
    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  4. NM_001355394.1 → NP_001342323.1  protein NDRG3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant (3). The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL669932, AL935150
    Conserved Domains (1) summary
    pfam03096
    Location:1 → 277
    Ndr; Ndr family

  5. NM_013865.2 → NP_038893.1  protein NDRG3 isoform 2

    See identical proteins and their annotated locations for NP_038893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AK004689, AV032677, BY125191
    Consensus CDS
    CCDS16971.1
    UniProtKB/Swiss-Prot
    Q9QYF9
    UniProtKB/TrEMBL
    Q544I1
    Related
    ENSMUSP00000072144.7, ENSMUST00000072298.13
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  6. NM_180956.1 → NP_851287.1  protein NDRG3 isoform 1

    See identical proteins and their annotated locations for NP_851287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AV032677, BC018504, BY125191
    Consensus CDS
    CCDS50780.1
    UniProtKB/TrEMBL
    Q8VCV2
    Related
    ENSMUSP00000070052.7, ENSMUST00000069600.13
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156769262..156834052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251734.1 → XP_030107594.1  protein NDRG3 isoform X4

    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  2. XM_030251736.2 → XP_030107596.1  protein NDRG3 isoform X5

    Conserved Domains (1) summary
    pfam03096
    Location:1 → 277
    Ndr; Ndr family

  3. XM_030251733.1 → XP_030107593.1  protein NDRG3 isoform X2

    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  4. XM_011239593.1 → XP_011237895.1  protein NDRG3 isoform X1

    See identical proteins and their annotated locations for XP_011237895.1

    UniProtKB/TrEMBL
    Q8VCV2
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  5. XM_030251732.1 → XP_030107592.1  protein NDRG3 isoform X1

    UniProtKB/TrEMBL
    Q8VCV2
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  6. XM_036162285.1 → XP_036018178.1  protein NDRG3 isoform X3

    UniProtKB/Swiss-Prot
    Q9QYF9
    UniProtKB/TrEMBL
    Q544I1
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  7. XM_036162283.1 → XP_036018176.1  protein NDRG3 isoform X1

    UniProtKB/TrEMBL
    Q8VCV2
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  8. XM_036162284.1 → XP_036018177.1  protein NDRG3 isoform X3

    UniProtKB/Swiss-Prot
    Q9QYF9
    UniProtKB/TrEMBL
    Q544I1
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  9. XM_017318968.1 → XP_017174457.1  protein NDRG3 isoform X3

    UniProtKB/Swiss-Prot
    Q9QYF9
    UniProtKB/TrEMBL
    Q544I1
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYF9.1 GenPept UniProtKB/Swiss-Prot:Q9QYF9

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