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Mga MAX gene associated [ Mus musculus (house mouse) ]

Gene ID: 29808, updated on 21-Apr-2024

Summary

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Official Symbol
Mgaprovided by MGI
Official Full Name
MAX gene associatedprovided by MGI
Primary source
MGI:MGI:1352483
See related
Ensembl:ENSMUSG00000033943 AllianceGenome:MGI:1352483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mad5; C130042M01Rik; D030062C11Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.0), CNS E11.5 (RPKM 2.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 59.97 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119702974..119800610)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119872503..119970129)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23814 Neighboring gene TYRO3 protein tyrosine kinase 3 Neighboring gene STARR-seq mESC enhancer starr_05497 Neighboring gene STARR-seq mESC enhancer starr_05498 Neighboring gene STARR-seq mESC enhancer starr_05499 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1252 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665 Neighboring gene predicted gene, 28042 Neighboring gene jumonji domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells. Uranishi K, et al. Stem Cells, 2021 Nov. PMID 34224650
  2. Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1. Kitamura Y, et al. Sci Rep, 2021 May 6. PMID 33958653, Free PMC Article
  3. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates. Qin J, et al. Sci Adv, 2021 Jan. PMID 33523934, Free PMC Article
  4. Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Burn SF, et al. Gene Expr Patterns, 2018 Jan. PMID 29066359, Free PMC Article
  5. Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis. Tanaskovic N, et al. Life Sci Alliance, 2022 Aug. PMID 35422437, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
    Title: SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
  2. Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells.
    Title: Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells.
  3. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates.
    Title: Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates.
  4. Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
    Title: Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
  5. Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.
    Title: Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.
  6. Loss of Mga expression in two gene-trap alleles results in embryonic lethality
    Title: Postimplantation Mga expression and embryonic lethality of two gene-trap alleles.
  7. These results suggest a mechanism whereby Mga influences pluripotent cell survival.
    Title: Mga is essential for the survival of pluripotent cells during peri-implantation development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAX gene-associated protein
Names
MAX-interacting protein
Max dimerization protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164274.1 → NP_001157746.1  MAX gene-associated protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AL954662
    Consensus CDS
    CCDS50675.1
    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    UniProtKB/TrEMBL
    H7BX50
    Related
    ENSMUSP00000078853.6, ENSMUST00000079934.12
    Conserved Domains (3) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:2194 → 2244
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:1038 → 1084
    DUF4801; Domain of unknown function (DUF4801)

  2. NM_013720.2 → NP_038748.2  MAX gene-associated protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF205935, AK046252, AK172962, AL954662, BQ552371, CD539587, CN725372
    Consensus CDS
    CCDS38208.1
    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    UniProtKB/TrEMBL
    E9QLG3
    Related
    ENSMUSP00000106401.2, ENSMUST00000110774.8
    Conserved Domains (4) summary
    pfam05109
    Location:1447 → 1775
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd18911
    Location:2403 → 2467
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
    pfam16059
    Location:1038 → 1079
    DUF4801; Domain of unknown function (DUF4801)
    cd20195
    Location:75 → 260
    T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119702974..119800610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499691.5 → XP_006499754.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006499754.1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  2. XM_006499689.3 → XP_006499752.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006499752.1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  3. XM_030251727.2 → XP_030107587.1  MAX gene-associated protein isoform X7

    Conserved Domains (3) summary
    pfam05109
    Location:53 → 280
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam03154
    Location:185 → 479
    Atrophin-1; Atrophin-1 family
    cd18911
    Location:908 → 972
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  4. XM_006499687.5 → XP_006499750.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006499750.1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  5. XM_006499690.5 → XP_006499753.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006499753.1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  6. XM_006499688.5 → XP_006499751.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006499751.1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  7. XM_011239591.3 → XP_011237893.1  MAX gene-associated protein isoform X5

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (3) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    cd18911
    Location:2244 → 2308
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  8. XM_011239592.3 → XP_011237894.1  MAX gene-associated protein isoform X6

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (4) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1395 → 1766
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    cd18911
    Location:2195 → 2259
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  9. XM_011239589.4 → XP_011237891.1  MAX gene-associated protein isoform X3

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1619 → 1913
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1400 → 1701
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2342 → 2406
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  10. XM_011239590.4 → XP_011237892.1  MAX gene-associated protein isoform X4

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1570 → 1864
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1363 → 1652
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2293 → 2357
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  11. XM_017318962.3 → XP_017174451.1  MAX gene-associated protein isoform X1

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    Conserved Domains (5) summary
    cd00182
    Location:74 → 264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:1729 → 2023
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:1038 → 1080
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:1510 → 1811
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:2452 → 2516
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

  12. XM_036162282.1 → XP_036018175.1  MAX gene-associated protein isoform X2

    UniProtKB/Swiss-Prot
    A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
    UniProtKB/TrEMBL
    E9QLG3
    Conserved Domains (4) summary
    pfam05109
    Location:1447 → 1775
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd18911
    Location:2403 → 2467
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
    pfam16059
    Location:1038 → 1079
    DUF4801; Domain of unknown function (DUF4801)
    cd20195
    Location:75 → 260
    T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

  13. XM_006499698.5 → XP_006499761.1  MAX gene-associated protein isoform X7

    See identical proteins and their annotated locations for XP_006499761.1

    Conserved Domains (3) summary
    pfam05109
    Location:53 → 280
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam03154
    Location:185 → 479
    Atrophin-1; Atrophin-1 family
    cd18911
    Location:908 → 972
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

RNA

  1. XR_866291.3 RNA Sequence

  2. XR_004940623.1 RNA Sequence

  3. XR_866290.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AWL7.1 GenPept UniProtKB/Swiss-Prot:A2AWL7

Gene LinkOut

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