U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snx10 sorting nexin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297096, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Snx10provided by RGD
Official Full Name
sorting nexin 10provided by RGD
Primary source
RGD:1305782
See related
Ensembl:ENSRNOG00000011944 AllianceGenome:RGD:1305782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol binding activity and ATPase binding activity. Predicted to be involved in several processes, including endosome organization; osteoclast differentiation; and protein localization to organelle. Predicted to act upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Predicted to be located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Predicted to be extrinsic component of endosome membrane. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 263.1), Lung (RPKM 101.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (81943262..82007667)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (80612648..80677005)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (81311490..81375248)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chromobox 3 Neighboring gene igE-binding protein-like Neighboring gene translocase of outer mitochondrial membrane 20 like 2 Neighboring gene MICOS complex subunit MIC13-like Neighboring gene uncharacterized LOC120102272 Neighboring gene uncharacterized LOC120102273 Neighboring gene uncharacterized LOC120102274 Neighboring gene uncharacterized LOC134486768

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats. Cervantes-Anaya N, et al. Tumour Biol, 2017 Apr. PMID 28381192
  2. Sorting nexin 10 induces giant vacuoles in mammalian cells. Qin B, et al. J Biol Chem, 2006 Dec 1. PMID 17012226
  3. SNX10 is required for osteoclast formation and resorption activity. Zhu CH, et al. J Cell Biochem, 2012 May. PMID 22174188
  4. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. Ye L, et al. PLoS Genet, 2015 Mar. PMID 25811986, Free PMC Article
  5. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Chen Y, et al. Cell Res, 2012 Feb. PMID 21844891, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the binomial miRNA 30d- SNX10 acts as a potential tumor oncogene suppressor by behaving as a dual tumor marker and a dual therapeutic target in liver cancer.
    Title: Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109202

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastric acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tooth eruption ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sorting nexin-10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013085.1 → NP_001013103.1  sorting nexin-10

    See identical proteins and their annotated locations for NP_001013103.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091290
    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    81943262..82007667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107307.2 → XP_038963235.1  sorting nexin-10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Related
    ENSRNOP00000016265.5
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. XM_006236486.5 → XP_006236548.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236548.1

    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  3. XM_006236490.3 → XP_006236552.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236552.1

    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  4. XM_006236489.5 → XP_006236551.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236551.1

    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  5. XM_006236488.5 → XP_006236550.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236550.1

    UniProtKB/TrEMBL
    A0A8I6APC8, Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous