U.S. flag

An official website of the United States government

GTF2F2 general transcription factor IIF subunit 2 [ Homo sapiens (human) ]

Gene ID: 2963, updated on 10-Dec-2024

Summary

Official Symbol
GTF2F2provided by HGNC
Official Full Name
general transcription factor IIF subunit 2provided by HGNC
Primary source
HGNC:HGNC:4653
See related
Ensembl:ENSG00000188342 MIM:189969; AllianceGenome:HGNC:4653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTF4; RAP30; TF2F2; TFIIF
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of transcription by RNA polymerase II; transcription elongation by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Located in microtubule cytoskeleton and nucleoplasm. Part of transcription factor TFIIF complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in skin (RPKM 5.5), adrenal (RPKM 5.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GTF2F2 in Genome Data Viewer
Location:
13q14.12-q14.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45120510..45284893)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44340562..44504949)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45694645..45859028)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 3 Neighboring gene uncharacterized LOC101929259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45694275-45694918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45694919-45695560 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:45697873-45698066 Neighboring gene RN7SK pseudogene 4 Neighboring gene RNA, U6 small nuclear 69, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5311 Neighboring gene uncharacterized LOC124903168 Neighboring gene potassium channel tetramerization domain containing 4 Neighboring gene uncharacterized LOC105370190 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45883380-45884072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:45904287-45904787 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIF, during Tat-mediated transactivation of the HIV-1 LTR PubMed
tat TFIIF synergizes with HIV-1 Tat and the cellular co-activator Tat-SF1 during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with the RAP30 subunit of TFIIF as demonstrated by Tat-affinity column purification PubMed
tat TFIIF is required for both basal and HIV-1 Tat-activated transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding  
enables RNA polymerase II general transcription initiation factor activity  
enables double-stranded DNA helicase activity  
enables forked DNA-dependent helicase activity  
enables four-way junction helicase activity  
enables protein binding PubMed 
enables single-stranded 3'-5' DNA helicase activity  
Component Evidence Code Pubs
located_in microtubule cytoskeleton  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus PubMed 
part_of transcription factor TFIIF complex  
part_of transcription factor TFIIF complex PubMed 

General protein information

Preferred Names
general transcription factor IIF subunit 2
Names
ATP-dependent helicase GTF2F2
TFIIF-beta
general transcription factor IIF 30 kDa subunit
general transcription factor IIF, polypeptide 2, 30kDa
transcription initiation factor IIF subunit beta
transcription initiation factor RAP30
NP_004119.1
XP_011533354.1
XP_011533355.1
XP_016876040.1
XP_054230456.1
XP_054230457.1
XP_054230458.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004128.3NP_004119.1  general transcription factor IIF subunit 2

    See identical proteins and their annotated locations for NP_004119.1

    Status: VALIDATED

    Source sequence(s)
    AK291545, AL138963, BC001771, CA429230, CB124466, DB252856
    Consensus CDS
    CCDS9395.1
    UniProtKB/Swiss-Prot
    A6NNS5, P13984, Q5W0H3
    Related
    ENSP00000340823.6, ENST00000340473.8
    Conserved Domains (1) summary
    cl02122
    Location:6247
    TFIIF_beta; Transcription initiation factor IIF, beta subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    45120510..45284893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535052.4XP_011533354.1  general transcription factor IIF subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam02270
    Location:13262
    TFIIF_beta; Transcription initiation factor IIF, beta subunit
  2. XM_011535053.4XP_011533355.1  general transcription factor IIF subunit 2 isoform X3

    Conserved Domains (1) summary
    cd07980
    Location:5103
    TFIIF_beta; Transcription initiation factor IIF, beta subunit
  3. XM_017020551.2XP_016876040.1  general transcription factor IIF subunit 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    44340562..44504949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374481.1XP_054230456.1  general transcription factor IIF subunit 2 isoform X1

  2. XM_054374483.1XP_054230458.1  general transcription factor IIF subunit 2 isoform X3

  3. XM_054374482.1XP_054230457.1  general transcription factor IIF subunit 2 isoform X2

External link. Please review our privacy policy.