Btg2 BTG anti-proliferation factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Btg2provided by RGD
Official Full Name: BTG anti-proliferation factor 2provided by RGD
Primary source: RGD:2225
See related: Ensembl:ENSRNOG00000003300 AllianceGenome:RGD:2225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: An; Agl; Pc3; an-1; Tis21
Summary: Enables transcription corepressor activity. Involved in several processes, including negative regulation of neuron apoptotic process; response to electrical stimulus; and response to peptide hormone. Acts upstream of or within negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute necrotizing pancreatitis and brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1207.6), Spleen (RPKM 360.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48083931..48087690, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45531881..45535642, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (50913185..50916944, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation.
Title: The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation.
Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest.
Title: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest.
Btg2 mutation induces renal injury and impairs blood pressure control in female rats.
Title: Btg2 mutation induces renal injury and impairs blood pressure control in female rats.
Icariside II protects cardiomyocytes from hypoxiainduced injury by upregulating the miR75p/BTG2 axis and activating the PI3K/Akt signaling pathway.
Title: Icariside II protects cardiomyocytes from hypoxia‑induced injury by upregulating the miR‑7‑5p/BTG2 axis and activating the PI3K/Akt signaling pathway.
PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells.
Title: HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.
B-cell translocation gene 2 (BTG2) is a crucial regulator in GLP-1-induced insulin gene expression and insulin secretion via upregulation of pancreatic duodenal homeobox-1 (PDX-1) in pancreatic beta-cells.
Title: B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells.
These findings demonstrate the gonadotropin stimulation of Btg2 in the ovary and, the physical interaction of Btg2 with Ant2 in mitochondria.
Title: B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria.
the present study provides us with a novel molecular mechanism of BTG2-mediated induction of hepatic gluconeogenesis and suggests that BTG2 plays an important role in hepatic glucose metabolism.
Title: B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB.
Math1 was expressed on postnatal days 0 - 5 in rat greater epithelial ridge cells.
Title: [Expression of three kinds of transcription factors in greater epithelial ridge cells of rat cochlear].
These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea.
Title: PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P12 (e-PCR)
- UniSTS:271371

AA819837 (e-PCR)
- UniSTS:261837

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein BTG2

Names: B-cell translocation gene 2, anti-proliferative; BTG family, member 2; Early induced gene B-cell translocation gene 2; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; cell surface alloantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.