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GSN gelsolin [ Homo sapiens (human) ]

Gene ID: 2934, updated on 7-Apr-2024

Summary

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Official Symbol
GSNprovided by HGNC
Official Full Name
gelsolinprovided by HGNC
Primary source
HGNC:HGNC:4620
See related
Ensembl:ENSG00000148180 MIM:137350; AllianceGenome:HGNC:4620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADF; AGEL
Summary
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q33.2
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121201483..121332842)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133397510..133528852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123963761..124095120)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene centriolin Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene RAB14, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124023585-124024084 Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20233 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:124043752-124044951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124047035-124047535 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:124048350-124049549 Neighboring gene Sharpr-MPRA regulatory region 178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124056667-124057289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124061747-124062407 Neighboring gene GSN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124089303-124090216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28922 Neighboring gene uncharacterized LOC102723324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124132533-124133493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:124148517-124149463 Neighboring gene stomatin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124215525-124216026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124216027-124216526 Neighboring gene NANOG hESC enhancer GRCh37_chr9:124234601-124235163 Neighboring gene glycoprotein alpha-galactosyltransferase 1 (inactive) Neighboring gene RNA, 7SL, cytoplasmic 187, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role and therapeutic potential of gelsolin in atherosclerosis. Zhang Q, et al. J Mol Cell Cardiol, 2023 May. PMID 36967105
  2. GSN gene frameshift mutations in Alzheimer's disease. Jiang Y, et al. J Neurol Neurosurg Psychiatry, 2023 Jun. PMID 36650038, Free PMC Article
  3. Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance. Onuma T, et al. Cells, 2022 Oct 20. PMID 36291171, Free PMC Article
  4. Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment. Hsieh CH, et al. Kaohsiung J Med Sci, 2022 Sep. PMID 35942641
  5. Gelsolin Contributes to the Motility of A375 Melanoma Cells and This Activity Is Mediated by the Fibrous Extracellular Matrix Protein Profile. Mazurkiewicz E, et al. Cells, 2021 Jul 21. PMID 34440617, Free PMC Article

See all (342) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
    Title: Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
  2. The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
    Title: The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
  3. Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
    Title: Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
  4. mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
    Title: mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
  5. GSN gene frameshift mutations in Alzheimer's disease.
    Title: GSN gene frameshift mutations in Alzheimer's disease.
  6. Role and therapeutic potential of gelsolin in atherosclerosis.
    Title: Role and therapeutic potential of gelsolin in atherosclerosis.
  7. Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
    Title: Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
  8. HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
    Title: HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
  9. Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
    Title: Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
  10. Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.
    Title: Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.
Submit: New GeneRIF Correction See all GeneRIFs (177)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Meretoja syndrome
MedGen: C1622345 OMIM: 105120 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp313L0718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables myosin II binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament severing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein processing in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of plasma membrane raft polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in renal protein absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to muscle stretch ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sequestering of actin monomers IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in striated muscle atrophy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cap IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in blood microparticle HDA PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
gelsolin
Names
actin-depolymerizing factor
brevin
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012872.2 RefSeqGene

    Range
    72081..136761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000177.5 → NP_000168.1  gelsolin isoform a precursor

    See identical proteins and their annotated locations for NP_000168.1

    Status: REVIEWED

    Source sequence(s)
    BC026033, DB250757
    Consensus CDS
    CCDS6828.1
    UniProtKB/Swiss-Prot
    A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, P06396, Q5T0I2, Q8WVV7
    UniProtKB/TrEMBL
    A0A384MEF1, B7Z9A0
    Related
    ENSP00000362924.4, ENST00000373818.8
    Conserved Domains (6) summary
    cd11288
    Location:561 → 649
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:186 → 275
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:59 → 171
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:666 → 764
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:295 → 395
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:439 → 539
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_001127662.2 → NP_001121134.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121134.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA450851
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  3. NM_001127663.2 → NP_001121135.2  gelsolin isoform f

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA294394, DA394782
    Consensus CDS
    CCDS75890.1
    UniProtKB/TrEMBL
    A0A0A0MT01, B7Z6N2
    Related
    ENSP00000409358.2, ENST00000449733.7
    Conserved Domains (6) summary
    cd11288
    Location:546 → 634
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:171 → 260
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:44 → 156
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:651 → 749
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:280 → 380
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:424 → 524
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  4. NM_001127664.2 → NP_001121136.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121136.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA294394, DB170452
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  5. NM_001127665.2 → NP_001121137.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121137.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC370937
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  6. NM_001127666.2 → NP_001121138.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121138.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC341948
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000362914.3, ENST00000373808.8
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  7. NM_001127667.2 → NP_001121139.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121139.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC316173
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  8. NM_001258029.2 → NP_001244958.1  gelsolin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS75891.1
    UniProtKB/TrEMBL
    A0A0A0MS51, B7Z992
    Related
    ENSP00000377882.3, ENST00000394353.7
    Conserved Domains (6) summary
    cd11288
    Location:527 → 615
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:152 → 241
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:25 → 137
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:632 → 730
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:261 → 361
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:405 → 505
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  9. NM_001258030.2 → NP_001244959.1  gelsolin isoform e

    Status: REVIEWED

    Source sequence(s)
    AK295572, AK299453, AL513122, BC017491, DC378873
    Consensus CDS
    CCDS65118.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000445823.1, ENST00000545652.6
    Conserved Domains (6) summary
    cd11288
    Location:518 → 606
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:143 → 232
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:16 → 128
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:623 → 721
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:252 → 352
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:396 → 496
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  10. NM_001353053.1 → NP_001339982.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL137068, AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  11. NM_001353054.1 → NP_001339983.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL137068, AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000362929.2, ENST00000373823.7
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  12. NM_001353055.2 → NP_001339984.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  13. NM_001353056.2 → NP_001339985.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  14. NM_001353057.2 → NP_001339986.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  15. NM_001353058.2 → NP_001339987.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  16. NM_001353059.2 → NP_001339988.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  17. NM_001353060.2 → NP_001339989.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  18. NM_001353061.2 → NP_001339990.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  19. NM_001353062.1 → NP_001339991.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  20. NM_001353063.2 → NP_001339992.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  21. NM_001353064.2 → NP_001339993.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  22. NM_001353065.2 → NP_001339994.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  23. NM_001353066.2 → NP_001339995.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  24. NM_001353067.2 → NP_001339996.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  25. NM_001353068.2 → NP_001339997.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  26. NM_001353069.2 → NP_001339998.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  27. NM_001353070.2 → NP_001339999.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  28. NM_001353071.2 → NP_001340000.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  29. NM_001353072.2 → NP_001340001.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  30. NM_001353073.2 → NP_001340002.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  31. NM_001353074.2 → NP_001340003.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  32. NM_001353075.1 → NP_001340004.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  33. NM_001353076.2 → NP_001340005.1  gelsolin isoform g

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS94475.1
    UniProtKB/TrEMBL
    A0A8V8TND7, B7Z9A0
    Related
    ENSP00000514432.1, ENST00000699558.1
    Conserved Domains (6) summary
    cd11288
    Location:534 → 622
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:159 → 248
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:32 → 144
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:639 → 737
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:268 → 368
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:412 → 512
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  34. NM_001353077.1 → NP_001340006.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  35. NM_001353078.2 → NP_001340007.1  gelsolin isoform h

    Status: REVIEWED

    Source sequence(s)
    AL513122
    UniProtKB/TrEMBL
    B3KS49
    Conserved Domains (4) summary
    cd11288
    Location:292 → 380
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:397 → 495
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:26 → 126
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:170 → 270
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  36. NM_198252.3 → NP_937895.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_937895.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000404226.2, ENST00000432226.7
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    121201483..121332842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423273.1 → XP_047279229.1  gelsolin isoform X5

  2. XM_047423267.1 → XP_047279223.1  gelsolin isoform X4

  3. XM_047423268.1 → XP_047279224.1  gelsolin isoform X4

  4. XM_047423272.1 → XP_047279228.1  gelsolin isoform X5

  5. XM_047423265.1 → XP_047279221.1  gelsolin isoform X1

  6. XM_017014645.2 → XP_016870134.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    B7Z9A0
    Conserved Domains (6) summary
    cd11288
    Location:531 → 619
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:156 → 245
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:29 → 141
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:636 → 734
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:265 → 365
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:409 → 509
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  7. XM_047423271.1 → XP_047279227.1  gelsolin isoform X4

  8. XM_011518585.2 → XP_011516887.1  gelsolin isoform X2

    UniProtKB/TrEMBL
    B7Z9A0
    Conserved Domains (6) summary
    cd11288
    Location:540 → 628
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:165 → 254
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:38 → 150
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:645 → 743
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:274 → 374
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:418 → 518
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  9. XM_047423270.1 → XP_047279226.1  gelsolin isoform X4

  10. XM_047423266.1 → XP_047279222.1  gelsolin isoform X3

  11. XM_047423269.1 → XP_047279225.1  gelsolin isoform X4

  12. XM_005251944.2 → XP_005252001.1  gelsolin isoform X4

    See identical proteins and their annotated locations for XP_005252001.1

    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  13. XM_011518594.2 → XP_011516896.1  gelsolin isoform X6

    Conserved Domains (5) summary
    cd11288
    Location:352 → 440
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:457 → 555
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:86 → 186
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:230 → 330
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:12 → 66
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    133397510..133528852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362811.1 → XP_054218786.1  gelsolin isoform X1

  2. XM_054362812.1 → XP_054218787.1  gelsolin isoform X1

  3. XM_054362815.1 → XP_054218790.1  gelsolin isoform X3

  4. XM_054362818.1 → XP_054218793.1  gelsolin isoform X4

  5. XM_054362813.1 → XP_054218788.1  gelsolin isoform X2

  6. XM_054362817.1 → XP_054218792.1  gelsolin isoform X4

  7. XM_054362814.1 → XP_054218789.1  gelsolin isoform X3

  8. XM_054362816.1 → XP_054218791.1  gelsolin isoform X4

  9. XM_054362819.1 → XP_054218794.1  gelsolin isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06396.1 GenPept UniProtKB/Swiss-Prot:P06396

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