BRD7 bromodomain containing 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRD7provided by HGNC
Official Full Name: bromodomain containing 7provided by HGNC
Primary source: HGNC:HGNC:14310
See related: Ensembl:ENSG00000166164 MIM:618489; AllianceGenome:HGNC:14310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BP75; NAG4; CELTIX1; SMARCI1
Summary: This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (50315957..50368988, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (56113791..56166835, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (50349868..50402899, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.
Title: Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Title: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
Title: Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.
Title: LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.
BRD7 restrains TNF-alpha-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
Title: BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.
Title: Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.
Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.
Title: Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.
PARP1 induces the degradation of BRD7.
Title: Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.
c-Myc transactivates miR-141 expression and that BRD7, a direct target of c-Myc, serves as a cofactor of c-Myc and forms a negative feedback loop with c-Myc in miR-141 transcription in NPC.
Title: BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
BRD7 was positively correlated with BAK levels in breast cancer tissues, and the survival rate of patients with low BAK and BRD7 expression was significantly lower than that of patients with high BAK and BRD7 expression. In addition, BRD7 activated BAK promoter activity and induced BAK expression in an indirect manner.
Title: Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of liver enzymes in korean children. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-2534 (e-PCR)
- UniSTS:43274

RH18317 (e-PCR)
- UniSTS:88365

BRD7 (e-PCR)
- UniSTS:503397

SHGC-64341 (e-PCR)
- UniSTS:22889

D3S2934E (e-PCR)
- UniSTS:150918

RH68546 (e-PCR)
- UniSTS:47505

RH12903 (e-PCR)
- UniSTS:86444

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bromodomain-containing protein 7

Names: 75 kDa bromodomain protein; protein CELTIX-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023418.2 RefSeqGene

Range

5000..58031

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001173984.3 → NP_001167455.1 bromodomain-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_001167455.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC007493, AC007597, AF152604, AF213969, AW615116

Consensus CDS

CCDS54007.1

UniProtKB/TrEMBL

A0AA34QW01

Related

ENSP00000378181.2, ENST00000394689.2

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 533

DUF3512; Domain of unknown function (DUF3512)
NM_013263.5 → NP_037395.2 bromodomain-containing protein 7 isoform 2

See identical proteins and their annotated locations for NP_037395.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.

Source sequence(s)

AC007493, AC007597, AF152604, AW615116, DA645362

Consensus CDS

CCDS10742.1

UniProtKB/Swiss-Prot

Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9NPI1, Q9UH59

UniProtKB/TrEMBL

A0AA34QW01

Related

ENSP00000378180.3, ENST00000394688.8

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 532

DUF3512; Domain of unknown function (DUF3512)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

50315957..50368988 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017023180.2 → XP_016878669.1 bromodomain-containing protein 7 isoform X6

UniProtKB/TrEMBL

A0AA34QW01
XM_017023179.2 → XP_016878668.1 bromodomain-containing protein 7 isoform X5

UniProtKB/TrEMBL

A0AA34QW01
XM_011523049.3 → XP_011521351.1 bromodomain-containing protein 7 isoform X4

UniProtKB/TrEMBL

A0AA34QW01

Conserved Domains (2) summary

cd05513
Location:152 → 249

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:304 → 513

DUF3512; Domain of unknown function (DUF3512)
XM_011523048.3 → XP_011521350.1 bromodomain-containing protein 7 isoform X3

UniProtKB/TrEMBL

A0AA34QW01

Conserved Domains (2) summary

cd05513
Location:152 → 249

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:304 → 514

DUF3512; Domain of unknown function (DUF3512)
XM_011523047.3 → XP_011521349.1 bromodomain-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0AA34QVS2, A0AA34QW01

Related

ENSP00000518227.1, ENST00000710356.1

Conserved Domains (2) summary

cd05513
Location:152 → 249

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:304 → 549

DUF3512; Domain of unknown function (DUF3512)
XM_011523046.4 → XP_011521348.1 bromodomain-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0AA34QW01

Conserved Domains (2) summary

cd05513
Location:152 → 249

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:304 → 550

DUF3512; Domain of unknown function (DUF3512)
XM_047434006.1 → XP_047289962.1 bromodomain-containing protein 7 isoform X7
XM_011523050.4 → XP_011521352.1 bromodomain-containing protein 7 isoform X10

Conserved Domains (2) summary

pfam12024
Location:85 → 331

DUF3512; Domain of unknown function (DUF3512)

cl02556
Location:1 → 30

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_047434008.1 → XP_047289964.1 bromodomain-containing protein 7 isoform X9
XM_047434007.1 → XP_047289963.1 bromodomain-containing protein 7 isoform X8

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

56113791..56166835 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054380174.1 → XP_054236149.1 bromodomain-containing protein 7 isoform X6
XM_054380173.1 → XP_054236148.1 bromodomain-containing protein 7 isoform X5
XM_054380172.1 → XP_054236147.1 bromodomain-containing protein 7 isoform X4
XM_054380171.1 → XP_054236146.1 bromodomain-containing protein 7 isoform X3
XM_054380170.1 → XP_054236145.1 bromodomain-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0AA34QVS2
XM_054380169.1 → XP_054236144.1 bromodomain-containing protein 7 isoform X1
XM_054380175.1 → XP_054236150.1 bromodomain-containing protein 7 isoform X7
XM_054380178.1 → XP_054236153.1 bromodomain-containing protein 7 isoform X10
XM_054380177.1 → XP_054236152.1 bromodomain-containing protein 7 isoform X9
XM_054380176.1 → XP_054236151.1 bromodomain-containing protein 7 isoform X8